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FLASH GENE
Symbol GCC1 contributors: mct/npt - updated : 12-04-2010
HGNC name GRIP and coiled-coil domain containing 1
HGNC id 19095
Location 7q32.1      Physical location : 127.220.682 - 127.225.654
Synonym name
  • golgi coiled-coil 1
  • peripheral membrane Golgi protein
  • Synonym symbol(s) FLJ22035, GCC88, MGC20706, GCC1P
    DNA
    TYPE functioning gene
    STRUCTURE 4.97 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4152 - 775 - Lieu (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a coiled coil domain
  • targeted to trans-Golgi network (TGN) membranes by its C-terminal GRIP domain in a G-protein-dependent process (Derby 2004)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport
  • GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
  • defines a retrograde transport pathway from early endosomes to the trans-Golgi network (Lieu 2007)
  • essential role in the localization of trans-Golgi network fusion machinery for transport from early endosomes to the trans-Golgi network (Lieu 2007)
  • recruited to functionally distinct domains of the TGN and are likely to be important for the maintenance of TGN subdomain structure, a critical feature for mediating protein sorting and membrane transport (Derby 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form parallel coiled-coil dimers (Luke 2005)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS