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FLASH GENE
Symbol GBP1 contributors: mct - updated : 01-10-2016
HGNC name guanylate binding protein 1, interferon-inducible, 67kDa
HGNC id 4182
Location 1p22.2      Physical location : 89.517.986 - 89.531.043
Synonym name
  • interferon-induced guanylate-binding protein 1
  • GTP-binding protein 1
  • guanine nucleotide-binding protein 1
  • DNA
    TYPE anonymous DNA segment
    STRUCTURE 13.06 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure
  • TP53 response element (p53RE) present in the GBP1 promoter region
  • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3050 - 592 - 2003 12881412
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal modified G domain a
  • a C terminal region constituting an extended helical domain with unique features, C-terminal CaaX-prenylation signal, which is typical for small GTPases of the Ras family, and increases the membrane affinity of proteins
  • HOMOLOGY
    Homologene
    FAMILY dynamin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • prenylated and prenylation is required for the membrane association
  • GBP1, GBP3, and GBP5 were exclusively detected in the cytoplasm, whereas GBP2 and GBP4 displayed a nucleocytoplasmic distribution
  • basic FUNCTION
  • GTPase converting GTP to GMP
  • mediating an antiviral effect against stomatites virus and encephalomyocarditis virus
  • key mediator of the inhibitory effects of inflammatory cytokines on endothelial cells proliferation and invasiveness
  • acting as a major regulator of the anti-angiogenic response of endothelial cells to inflammatory cytokines
  • may be used as a marker to monitor the inflammatory cytokines (IC)-induced phenotype of endothelial cells (EC) in inflammation and may also be exploited as a target to modulate EC activity in inflammatory diseases and tumor angiogenesis
  • marker and intracellular regulator of the inhibition of proliferation, migration and invasion of endothelial cells induced by several pro-inflammatory cytokines
  • contributes to vascular dysfunction in chronic inflammatory diseases by inhibiting endothelial progenitor cells (EPC) angiogenic activity via the induction of premature EPC differentiation
  • GBP1, GBP2 and GBP5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner
  • GBP1 and GBP3 possess anti-influenza viral activity
  • acts directly as a tumor suppressor in colorectalcarcinoma and the loss of GBP1 expression might indicate tumor evasion from the IFNG-dominated Th1 immune response
  • plays an important role in antitumor and antiviral immune responses
  • is a novel member within the family of actin-remodeling proteins specifically mediating IFNG-dependent defense strategies
  • IFNG-inducible guanylate binding protein 1 (GBP1) is a regulator of T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • binds and hydrolyses GTP thereby undergoing structural changes which lead to self-assembly of the protein
  • protein
  • guanylate binding
  • TP53 positively regulated GBP1 transcription via binding to the TP53 response element (p53RE) present in the GBP1 promoter region
  • is a downstream processor of IFNG via which T cells regulate cytoskeleton-dependent cell functions 8)
  • GBP1 facilitated CASP4 recruitment to Salmonella leading to its enhanced activation and pyroptosis
  • cell & other
    REGULATION
    induced by interferon inducible
    IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) inducing the expression of GBP1, GBP2, and GBP3 at similar high levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene may be a useful surrogate marker for diagnosis of bacterial meningitis
    Marker
    Therapy target
    ANIMAL & CELL MODELS