basic FUNCTION
| involved in regulating terminal differentiation and/or proliferation |
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play critical roles in restricting cell lineage differentiation during development (primary function during cardiovascular development is to regulate morphogenetic patterning of the cardiac outflow tract and aortic arch) |
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in human fetal testis, GATA6 is linked to the expression level of Bax and BCL2 |
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endodermal transcription factor having a protective function in lung epithelial cells exposed to P. aeruginosa  |
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play an important role in adrenal steroid biosynthesis  |
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may play a dominant role in cardiac outflow tract development, although it has been reported to have a redundant role with GATA4 during cardiogenesis  |
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essential for differentiation of visceral mesoderm and morphogenetic patterning of cardiac outflow tract and large arteries  |
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also plays a role in chondrogenesis and LGR5 is a potential direct target of GATA regulation in this process  |
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may regulate expression of the calreticulin gene during cardiac development  |
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promotes angiogenic function and survival in endothelial cells by suppression of TGFBR1) |
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key role for the transcription factor GATA6 in human pancreatic development  |
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GATA4 and GATA6 are needed for normal ovarian function  |
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implicated in the development of multiple organ systems, including the biliary tract, gut, pituitary and thyroid, as well as the pancreas  |
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GATA4, GATA45, GATA6 are indispensable for the lineage-specific development and differentiation of cells of endodermal and mesodermal origin  |
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promotes cell survival by regulating endoderm expression of BMP2 and basement membrane (BM)during embryonic epithelial morphogenesis  |
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in the colorectal epithelium, directs cell proliferation, differentiation and apoptosis  |