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FLASH GENE
Symbol GAST contributors: mct - updated : 26-09-2013
HGNC name gastrin
HGNC id 4164
Location 17q21.2      Physical location : 39.868.612 - 39.872.220
Synonym name
  • preprogastrin
  • Synonym symbol(s) GAS
    DNA
    TYPE functioning gene
    STRUCTURE 0.54 kb     2 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 475 - 101 - 2004 1511518
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestineduodenum moderately Homo sapiensAdult
    Endocrinepancreas   moderately Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor Progastrin is processed to a number of peptides including glycine-extended gastrin, amidated gastrin and the C-terminal flanking peptide (CTFP)
    HOMOLOGY
    interspecies homolog to murine Gas
    Homologene
    FAMILY gastrin/cholecystokinin family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • stimulating the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes
  • secreted from neuroendocrine cells residing in the adult antrum called G cells
  • normally regulates gastric acid secretion by stimulating the proliferation of enterochromaffin-like cells and the release of histamine
  • C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway
  • might alter colonic epithelial cells via indirect mechanisms to promote neoplasia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • gastrin bind two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated gastrins
  • protein
  • regulation of TFF2 by gastrin may play a role in the maintenance and repair of the gastrointestinal mucosa
  • proximal DNA elements within the GAST promoter mediate interactions between JUND, which induces GAST gene expression and MEN1, which suppresses JUND-mediated activation
  • clathrin mediates endocytosis of gastrin and activates MAPKs, with a role of cell surface annexin A2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS