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FLASH GENE

Symbol

GAS8

contributors: mct/npt - updated : 12-11-2015

HGNC name	growth arrest-specific 8
HGNC id	4166

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ICS35 immotile cilia syndrome 35
Location	16q24.3      Physical location : 90.089.007 - 90.111.379
Synonym name	growth arrest-specific 11
	dynein regulatory complex subunit 4
Synonym symbol(s)	GAS11, DRC4

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene, opposite orientation
text	containing in the 2nd intron, an apparently intronless gene, c16orf3 that is transcribed in opposite orientation to GAS11
STRUCTURE	25.34 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001481 11 polyA site 3185 NP_001472 56.4 478 - 2002 11751847 ubiquitously variant 2 - polyA site 1800 isoform 2 - - - 2002 11751847 ubiquitously NM_001286205 11 - 3308 NP_001273134 - 395 heart and skeletal muscle 2002 11751847 NM_001286208 10 - 3253 NP_001273137 - 286 skeletal muscle 2002 11751847 NM_001286209 11 - 3200 NP_001273138 - 453 - 2002 11751847

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine       Nervous brain         Urinary kidney         Visual eye anterior segment iris

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

cell cycle

cell cycle

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C terminus is important for both GAS8 interaction with SMO and facilitating SMO signaling

HOMOLOGY

interspecies

ortholog to murine Gas11

Homologene

FAMILY

GAS8 family

CATEGORY

tumor suppressor , signaling growth factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule
text	associates with microtubules (Bekker 2007)
	associated with the detergent-insoluble cytoskeleton and exhibits a juxtanuclear localization that overlaps with the pericentrosomal Golgi apparatus (Colantonio 2006)

basic FUNCTION	negative control of cell proliferation
	microtubule associated subunit of the Dynein Regulatory Complex (DRC)
	is a positive regulator of Hh signaling that cooperates with GRK2 to control SMO signaling
	nexin-dynein regulatory complex component

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with RAB3B (links RAB3B to microtubules in NIH 3T3 cells) (Nishimura 2008)
	associate with CCDC65
	GAS8 (DRC4) function is essential for axonemal localization of DRC3

cell & other

direct linkage to microtubules provides new mechanistic insight into the structural features of the dynein-regulatory complex (Bekker 2007)

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICS35

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     and LOH in breast and prostate carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS