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FLASH GENE
Symbol GAS8 contributors: mct/npt - updated : 12-11-2015
HGNC name growth arrest-specific 8
HGNC id 4166
Corresponding disease
ICS35 immotile cilia syndrome 35
Location 16q24.3      Physical location : 90.089.007 - 90.111.379
Synonym name
  • growth arrest-specific 11
  • dynein regulatory complex subunit 4
  • Synonym symbol(s) GAS11, DRC4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene, opposite orientation
    text containing in the 2nd intron, an apparently intronless gene, c16orf3 that is transcribed in opposite orientation to GAS11
    STRUCTURE 25.34 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    DPEP1 16q24.3 dipeptidase 1 (renal) PCOLN3 16q24.3 procollagen (type III) N-endopeptidase FLJ31606 16q24.3 hypothetical protein FLJ31606 LOC388309 16 LOC388309 CDK10 16q24.3 cyclin-dependent kinase (CDC2-like) 10 MGC26885 16q24.3 hypothetical protein MGC26885 C16orf7 16q24 chromosome 16 open reading frame 7 ZFP276 16q24.3 zinc finger protein 276 homolog (mouse) FANCA 16q24.3 Fanconi anemia, complementation group A LOC197317 16q24.3 hypothetical LOC197317 Spir-2 16q24 Spir-2 protein KIAA1049 16q24.3 Spir-2 protein FLJ12547 16q24.3 hypothetical protein FLJ12547 MC1R 16q24.3 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) TUBB4 16q24.3 tubulin, beta, 4 FLJ20186 16q24.3 hypothetical protein FLJ20186 MGC13198 16q24.3 hypothetical protein MGC13198 MGC16385 16q24.3 hypothetical protein MGC16385 AFG3L1 16q24 AFG3 ATPase family gene 3-like 1 (yeast) MGC3101 16q24.3 hypothetical protein MGC3101 GAS8 16q24.3 growth arrest-specific 8 C16orf3 16q24.3 chromosome 16 open reading frame 3 PRDM7 16q24.3 PR domain containing 7 LOC197331 16q24.3 HSA16q24 beta-tubulin 4Q pseudogene LOC388311 16 LOC388311 LOC388312 16 hypothetical gene supported by AK128780 LOC388313 16 similar to bA476I15.3 (novel protein similar to septin)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 polyA site 3185 56.4 478 - 2002 11751847
    ubiquitously
    - polyA site 1800 - - - 2002 11751847
    ubiquitously
    11 - 3308 - 395 heart and skeletal muscle 2002 11751847
    10 - 3253 - 286 skeletal muscle 2002 11751847
    11 - 3200 - 453 - 2002 11751847
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestine   
    Nervousbrain    
    Urinarykidney    
    Visualeyeanterior segmentiris  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    cell cycle     cell cycle
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminus is important for both GAS8 interaction with SMO and facilitating SMO signaling
  • HOMOLOGY
    interspecies ortholog to murine Gas11
    Homologene
    FAMILY
  • GAS8 family
  • CATEGORY tumor suppressor , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • associates with microtubules (Bekker 2007)
  • associated with the detergent-insoluble cytoskeleton and exhibits a juxtanuclear localization that overlaps with the pericentrosomal Golgi apparatus (Colantonio 2006)
  • basic FUNCTION
  • negative control of cell proliferation
  • microtubule associated subunit of the Dynein Regulatory Complex (DRC)
  • is a positive regulator of Hh signaling that cooperates with GRK2 to control SMO signaling
  • nexin-dynein regulatory complex component
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAB3B (links RAB3B to microtubules in NIH 3T3 cells) (Nishimura 2008)
  • associate with CCDC65
  • GAS8 (DRC4) function is essential for axonemal localization of DRC3
  • cell & other
  • direct linkage to microtubules provides new mechanistic insight into the structural features of the dynein-regulatory complex (Bekker 2007)
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS35
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    and LOH in breast and prostate carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS