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FLASH GENE
Symbol GAS7 contributors: mct/npt - updated : 17-02-2010
HGNC name growth arrest-specific 7
HGNC id 4169
Location 17p13.1      Physical location : 9.813.925 - 10.101.868
Synonym name MLL/GAS7 fusion protein
Synonym symbol(s) KIAA0394, MGC1348, MLL/GAS7
DNA
TYPE functioning gene
STRUCTURE 287.94 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4 LOC124751 17p13.1 hypothetical protein LOC124751 RPL26 17p13 ribosomal protein L26 LOC390761 17 similar to RIKEN cDNA 9930039A11 gene NDEL1 17p13.1 nudE nuclear distribution gene E homolog like 1 (A. nidulans) MYH10 17p13.1 myosin, heavy polypeptide 10, non-muscle FLJ32734 17p13.1 hypothetical protein FLJ32734 LOC388333 17 similar to Williams-Beuren syndrome critical region protein 19 FLJ35773 17p13.1 hypothetical protein FLJ35773 P101-PI3K 17p13.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide p101 LOC388334 17 LOC388334 NTN1 17p13-p12 netrin 1 STX8 17p12 syntaxin 8 LOC146845 17p13.1 hypothetical protein LOC146845 USP43 17p12 ubiquitin specific protease 43 LOC201140 17p13.1 similar to DKFZP566O084 protein GLP2R 17p13.3 glucagon-like peptide 2 receptor RCV1 17p13.2 recoverin GAS7 17p13 growth arrest-specific 7 RPS27AP1 17 ribosomal protein S27a pseudogene 1 MYH13 17p13.1-p12 myosin, heavy polypeptide 13, skeletal muscle MYH8 17p13.1 myosin, heavy polypeptide 8, skeletal muscle, perinatal MYH4 17p13.1 myosin, heavy polypeptide 4, skeletal muscle MYH1 17p13.1 myosin, heavy polypeptide 1, skeletal muscle, adult MYH2 17p13.1 myosin, heavy polypeptide 2, skeletal muscle, adult MYH3 17p13.1 myosin, heavy polypeptide 3, skeletal muscle, embryonic SCO1 17p13-p12 SCO cytochrome oxidase deficient homolog 1 (yeast) MDS006 17p13.1 x 006 protein LOC388335 17 similar to RIKEN cDNA A730055C05 gene LOC388336 17 similar to hypothetical protein D430041B17
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing initiation site 7773 39.2 336 - Chao (2005)
14 splicing 8181 47.3 412 - Ishikawa, Chao (2005), Akiyama (2009)
  • GAS7B
  • Gas7b binds Tau and facilitates tubulin polymerization in a Tau-dependent manner
  • Tau contributes to the levels of GAS7B that are markedly down-regulated in brains from patients with Alzheimer disease
  • 14 - 8024 - 412 - Chao (2005)
    14 - 8211 - 746 - Chao (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Nervousbrainhindbraincerebellumcerebellar cortexhighly
     braindiencephalonhypothalamus highly
     brainlimbic systemhippocampus predominantly
    Reproductivemale systemprostate  lowly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Lymphoid    
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one WW domain
  • one FCH domain
  • F-BAR domain, which mediates oligomer formation and interactions with the submembrane region (You 2010)
  • C-terminal domains with the coiled-coil domain are essential for the submembrane localization that is required for GAS7-induced membrane protrusion formation (You 2010)
  • HOMOLOGY
    interspecies ortholog to murine Gas7
    homolog to Drosophila ade3
    homolog to C.elegans f38b6.4
    Homologene
    FAMILY
  • PCH (Pombe Cdc15 homology) protein family, PSTPIP subfamily
  • CATEGORY adaptor , transcription factor , protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in neurite formation
  • may play a role in promoting maturation and morphological differentiation of cerebellar neurons
  • playing a role in modulating neurotransmitter release
  • having an essential role through its interaction with WASL during neuronal maturation/differentiation (You 2010)
  • may be involved in neurite outgrowth through WASL-mediated actin organization in hippocampal neurons (You 2010)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text neuronal development, cell cycle arrest
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with F-actin and colocalizes with the terminal part of actin microfilament in cells in which membrane outgrowth is present
  • interaction between GAS7 and WASL is mediated by WW-Pro domains, which is unique in the PCH protein family, where most interactions are of the SH3-Pro kind (You 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(11;17)(q23;p13) with fusion MLL-GAS7 in acute myeloid leukemia
    constitutional       loss of function
    may be a key executive process to accelerate cellular dysfunction and death in the Tau pathology of Alzheimer disease (Akiyama 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS