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FLASH GENE
Symbol GAS7 contributors: mct/npt - updated : 17-02-2010
HGNC name growth arrest-specific 7
HGNC id 4169
Location 17p13.1      Physical location : 9.813.925 - 10.101.868
Synonym name MLL/GAS7 fusion protein
Synonym symbol(s) KIAA0394, MGC1348, MLL/GAS7
DNA
TYPE functioning gene
STRUCTURE 287.94 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing initiation site 7773 39.2 336 - Chao (2005)
14 splicing 8181 47.3 412 - Ishikawa, Chao (2005), Akiyama (2009)
  • GAS7B
  • Gas7b binds Tau and facilitates tubulin polymerization in a Tau-dependent manner
  • Tau contributes to the levels of GAS7B that are markedly down-regulated in brains from patients with Alzheimer disease
  • 14 - 8024 - 412 - Chao (2005)
    14 - 8211 - 746 - Chao (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Nervousbrainhindbraincerebellumcerebellar cortexhighly
     braindiencephalonhypothalamus highly
     brainlimbic systemhippocampus predominantly
    Reproductivemale systemprostate  lowly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Lymphoid    
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one WW domain
  • one FCH domain
  • F-BAR domain, which mediates oligomer formation and interactions with the submembrane region (You 2010)
  • C-terminal domains with the coiled-coil domain are essential for the submembrane localization that is required for GAS7-induced membrane protrusion formation (You 2010)
  • HOMOLOGY
    interspecies ortholog to murine Gas7
    homolog to Drosophila ade3
    homolog to C.elegans f38b6.4
    Homologene
    FAMILY
  • PCH (Pombe Cdc15 homology) protein family, PSTPIP subfamily
  • CATEGORY adaptor , transcription factor , protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in neurite formation
  • may play a role in promoting maturation and morphological differentiation of cerebellar neurons
  • playing a role in modulating neurotransmitter release
  • having an essential role through its interaction with WASL during neuronal maturation/differentiation (You 2010)
  • may be involved in neurite outgrowth through WASL-mediated actin organization in hippocampal neurons (You 2010)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text neuronal development, cell cycle arrest
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with F-actin and colocalizes with the terminal part of actin microfilament in cells in which membrane outgrowth is present
  • interaction between GAS7 and WASL is mediated by WW-Pro domains, which is unique in the PCH protein family, where most interactions are of the SH3-Pro kind (You 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(11;17)(q23;p13) with fusion MLL-GAS7 in acute myeloid leukemia
    constitutional       loss of function
    may be a key executive process to accelerate cellular dysfunction and death in the Tau pathology of Alzheimer disease (Akiyama 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS