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FLASH GENE
Symbol GAS2L3 contributors: mct - updated : 25-04-2015
HGNC name growth arrest-specific 2 like 3
HGNC id 27475
Location 12q23.1      Physical location : 100.967.488 - 101.018.683
Synonym name GAS2-like protein 3
Synonym symbol(s) LOC283431, G23L3
DNA
TYPE functioning gene
STRUCTURE 51.20 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2341 - 694 - 2011 21561867
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Hearing/Equilibriumear    
Reproductivefemale systemplacenta   
 female systemuteruscervix  
 female systembreastmammary gland  
Skin/Tegumentskin    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one CH (calponin-homology) domain, single calponin homology type 3 domain, for interacts with filamentous actin and Microtubules
  • a third domain, the GAR domain, does not directly bind to F-actin or MTs, but, it is involved in modulating the binding strength of GAS2L3 to each cytoskeletal system
  • HOMOLOGY
    Homologene
    FAMILY GAS2 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • localizes to the spindle midzone and the midbody during anaphase and cytokinesis, respectively
  • basic FUNCTION
  • may be involved in cell cycle arrest
  • microtubule-actin cross-linking protein
  • has the potential to communicate between MTs and actin
  • important roles of GAS2L3 for faithful cell division
  • GAS2L1, GAS2L2 and GAS2L3, are differentially involved in mediating the crosstalk between F-actin and microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both F-actin and MTs in cells via its CH domain and C terminus, respectively
  • target gene of KCNIP3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    causes chromosome loss and aneuploidy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS