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FLASH GENE
Symbol GAS2L1 contributors: mct - updated : 25-01-2015
HGNC name growth arrest-specific 2 like 1
HGNC id 16955
Location 22q12.2      Physical location : 29.702.996 - 29.708.774
Synonym name
  • GAS2-related on chromosome 22
  • mouse growth-arrest specific (Gas2) related gene
  • Synonym symbol(s) GAS2R, GAR22, MGC17243
    DNA
    TYPE functioning gene
    STRUCTURE 5.78 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2557 72.6 681 testis, brain 2011 21561867
  • G2L1beta, GAR22beta
  • localize and bind to both F-actin and MTs
  • induced in a variety of cultured cells by growth arrest
  • 6 - 2533 72.5 681 - 2011 21561867
    5 - 2963 36.3 337 - 2011 21561867
  • G2L1alpha, GAR22alpha
  • predominantly localize to the actin cytoskeleton
  • EXPRESSION
    Rna function mRNAs are expressed nearly ubiquitously
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one calponin homology domain
  • growth arrest specific protein 2 domain
  • HOMOLOGY
    interspecies homolog to murine growth-arrest specific (Gas2) gene
    Homologene
    FAMILY
  • GAS2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • hormone-induced GAS2L1 might represent an important trigger of growth inhibition induced by thyroid hormone in red cell progenitors
  • microtubule-actin cross-linking protein
  • GAS2L1, GAS2L2 and GAS2L3, are differentially involved in mediating the crosstalk between F-actin and microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLF9 and GAS2L1 are thyroid hormone receptors target genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS