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FLASH GENE
Symbol GAS2 contributors: - updated : 02-06-2007
HGNC name growth arrest-specific 2
HGNC id 4167
Location 11p15.2-p14.3      Physical location : 22.688.159 - 22.834.546
DNA
TYPE functioning gene
STRUCTURE 144.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Map pter - D11S921 - GAS2 - D11S359 - cen
Authors Collavin (99)
Physical map
LOC390101 11 similar to G protein-coupled receptor SNSR1 MRGX2 11p15.1 G protein-coupled receptor MRGX2 HIP14L 11p15.1 G protein-coupled receptor MRGX2 CSRP3 11p15.1 cysteine and glycine-rich protein 3 (cardiac LIM protein) FLJ23311 11p15.1 FLJ23311 protein LOC390102 11 similar to Proliferating cell nuclear antigen (PCNA) (Cyclin) NAV2 11p15.1 neuron navigator 2 LOC120237 11p15.1 similar to Homeobox protein DBX1 HTATIP2 11p15.1 HIV-1 Tat interactive protein 2, 30kDa PRMT3 11p15.1 protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3 SLC6A5 11p15.2-p15.1 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 NELL1 11p15.1-p15.2 NEL-like 1 (chicken) LOC203859 11p15.1 hypothetical protein LOC203859 SLC17A6 11p14.3 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 FANCF 11p15 Fanconi anemia, complementation group F GAS2 11p15.2-p14.3 growth arrest-specific 2 LOC196188 11p14.3 similar to ribosomal protein S2 LOC341002 11p14.3 similar to dJ568F9.1 (zinc finger protein 133 (clone pHZ-13)) LOC338645 11p14.3 hypothetical protein LOC338645 LOC390103 11 similar to amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2196 - 313 - Benetti
- - 2001 - 313 - Benetti
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to GAR22
Homologene
FAMILY maybe same family as GAR22
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • plays a role in regulating microfilament and cell shape changes during apoptosis
  • may play a role in apoptosis by acting as a cell death substrate for caspases
  • may enhance TP53 stability by inhibiting calpain activity
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis
  • interacts with m-calpain inhibits calpain-dependent processing of TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS