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FLASH GENE
Symbol GAPVD1 contributors: - updated : 09-06-2006
HGNC name GTPase activating protein and VPS9 domains 1
HGNC id 23375
Location 9q34.11      Physical location : 128.024.110 - 128.127.289
Synonym name Rab5-activating protein 6
Synonym symbol(s) KIAA1521, RAP6
DNA
TYPE functioning gene
STRUCTURE 103.00 kb     27 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Endocrinethyroid    
Hearing/Equilibriumear    
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Rab5 GEF
  • a Ras GAP domain
    • HOMOLOGY
    interspecies homolog to murine Gapvd1 (97.8pc)
    homolog to chicken GAPVD1 (93.5pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • regulator of endocytosis, exhibiting GEF activity specific for Rab5 and GAP activity specific for Ras
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS