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FLASH GENE
Symbol GALR2 contributors: mct/npt - updated : 08-02-2008
HGNC name galanin receptor 2
HGNC id 4133
Location 17q25.3      Physical location : 74.070.891 - 74.073.573
Synonym symbol(s) GALNR2, GAL2-R, MGC125983, MGC125984
DNA
TYPE functioning gene
STRUCTURE 2.68 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1309 41.6 387 - Tofighi (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • galanin receptor coupling to phospholipase C and elevation of intracellular calcium levels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding GALN with high affinity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with GAL at very high levels in pheochromocytoma tissues (Tofighi 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target galanin/GALR2 agonists may have future therapeutic implications for multiple sclerosis (Wraith 2009)
    ANIMAL & CELL MODELS