Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GALR1 contributors: mct/npt - updated : 07-03-2009
HGNC name galanin receptor 1
HGNC id 4132
Corresponding disease
DEL18QD chromosome 18q distal deletion
Location 18q23      Physical location : 74.962.007 - 74.982.094
Synonym symbol(s) GALNR1, GALNR, GAL1-R
DNA
TYPE functioning gene
STRUCTURE 20.10 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CYB5 18q23 cytochrome b-5 FAUP1 18 FBR-MuSV-associated ubiquitously expressed (fox derived) pseudogene 1 LOC125704 18q22.3 similar to hypothetical protein B230399E16 CN2 18q22.3 cytosolic nonspecific dipeptidase (EC 3.4.13.18) CN1 18q22.3 carnosinase 1 ZNF407 18q23 zinc finger protein 407 MGC45594 18q22.3 hypothetical protein MGC45594 SDCCAG33 18q22.3 serologically defined colon cancer antigen 33 LOC388482 18 LOC388482 LOC284275 18q23 hypothetical LOC284275 KIAA0222 18q23 hypothetical LOC284275 ZNF236 18q22-q23 zinc finger protein 236 MBP 18q23 myelin basic protein LOC388483 18 LOC388483 GALR1 18q23 galanin receptor 1 LOC390864 18 similar to amino acid feature: Rod protein domain, aa 266 .. 468; amino acid feature: globular protein domain, aa 32 .. 265 LOC125595 18q23 hypothetical LOC125595 LOC390865 18 similar to hypothetical protein LOC390866 18 LOC390866 LOC390867 18 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) LOC390868 18 similar to hypothetical protein LOC388484 18 LOC388484 SALL3 18q23 sal-like 3 (Drosophila) ATP9B 18q23 ATPase, Class II, type 9B NFATC1 18q23 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 LOC388485 18 LOC388485 LOC390869 18 similar to immediate early protein homolog LOC147294 18q23 similar to immediate early protein homolog FLJ25715 18q23 hypothetical protein FLJ25715 CTDP1 18q23 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 LOC390870 18 LOC390870 KCNG2 18q22-q23 potassium voltage-gated channel, subfamily G, member 2 FLJ22378 DIM1 FLJ21172 18q23 hypothetical protein FLJ21172 KIAA0863 18q23 KIAA0863 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2787 39 349 - Misawa (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a lysosomal signal motif on the cytoplasmic terminus (Xia 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text also coexpressed with GALN in ciliary epithelium
    basic FUNCTION
  • activating a variety of intracellular second-messenger pathways
  • tumor suppressor gene in HNSCC (head and neck squamous cell carcinoma) (Misawa 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    signaling through inhibition of adenylate cyclase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • linked to voltage gated calcium channel
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL18QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter hypermethylation and associated with prognosis, in head and neck cancer (Misawa 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for growth hormone deficiency in 18q- syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS