Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GALR1 contributors: mct/npt - updated : 07-03-2009
HGNC name galanin receptor 1
HGNC id 4132
Corresponding disease
DEL18QD chromosome 18q distal deletion
Location 18q23      Physical location : 74.962.007 - 74.982.094
Synonym symbol(s) GALNR1, GALNR, GAL1-R
DNA
TYPE functioning gene
STRUCTURE 20.10 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2787 39 349 - Misawa (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a lysosomal signal motif on the cytoplasmic terminus (Xia 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text also coexpressed with GALN in ciliary epithelium
    basic FUNCTION
  • activating a variety of intracellular second-messenger pathways
  • tumor suppressor gene in HNSCC (head and neck squamous cell carcinoma) (Misawa 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    signaling through inhibition of adenylate cyclase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • linked to voltage gated calcium channel
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL18QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter hypermethylation and associated with prognosis, in head and neck cancer (Misawa 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for growth hormone deficiency in 18q- syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS