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FLASH GENE

Symbol

GALNTL4

contributors: mct - updated : 10-06-2011

HGNC name	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
HGNC id	30488

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.3      Physical location : 11.292.420 - 11.643.561
Synonym symbol(s)	GALNT15, GalNAc-T15
EC.number	2.4.1.41

DNA

TYPE	functioning gene
STRUCTURE	351.00 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198516 11 - 2519 - 607 - 2010 20977886

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     predominantly Lymphoid/Immune thymus       highly Nervous brain       moderately Reproductive male system testis     highly Respiratory respiratory tract larynx     moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a ricin B-type lectin domain
	the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding
	the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Galntl4
	ortholog to chicken GALNTL4

Homologene

FAMILY	glycosyltransferase 2 family
	GalNAc-T subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	golgi stack
	integral to membrane
	type II membrane protein

basic FUNCTION

may catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

glycosylation

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	Ca2+
	Mn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS