Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GALNT6 contributors: mct - updated : 10-06-2011
HGNC name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
HGNC id 4128
Location 12q13.13      Physical location : 51.745.832 - 51.785.200
Synonym name
  • galactosamine:UDP-N-acetyl-alpha-D-polypeptide T6
  • pp-GaNTase 6
  • protein-UDP acetylgalactosaminyltransferase 6
  • Synonym symbol(s) GALNc-T6, GalNAcT6
    EC.number 2.4.1.41
    DNA
    TYPE functioning gene
    STRUCTURE 36.37 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ATF1 12q13.1-q13.2 activating transcription factor 1 MGC57341 12q13.13 hypothetical protein MGC57341 DKFZP586A0522 12q13.13 DKFZP586A0522 protein SLC11A2 12q13.1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 HCCR1 12q13.13 cervical cancer 1 protooncogene C12orf22 12q13.11-q13.12 chromosome 12 open reading frame 22 TFCP2 12q13.1 transcription factor CP2 POU6F1 12q13.1 POU domain, class 6, transcription factor 1 DAZAP2 2q33-q34 DAZ associated protein 2 LOC57228 12q13.13 hypothetical protein from clone 643 BIN2 4q22.1 bridging integrator 2 ELA1 12q13 elastase 1, pancreatic GALNT6 12q13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) LOC387857 12 LOC387857 SLC4A8 12q13 solute carrier family 4, sodium bicarbonate cotransporter, member 8 SCN8A 12q13 sodium channel, voltage gated, type VIII, alpha FLJ33996 12q13.13 hypothetical protein FLJ33996 DKFZp686O1689 12q13.13 hypothetical protein DKFZp686O1689 ACVRL1 12q13 activin A receptor type II-like 1 ACVR1B 12q13 activin A receptor, type IB GRASP 12q13.13 GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein NR4A1 12q13 nuclear receptor subfamily 4, group A, member 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4520 71 622 - 2010 20977886
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a hydrophobic anchor sequence near the N terminus
  • a stem region
  • a lumenal catalytic domain
  • a GT1 motif and Ga1/Ga1 NAc transferase motif
  • a C terminal ricin/lectin-like domain
  • a QXW lectin repeat
  • HOMOLOGY
    intraspecies homolog to GALNT3
    Homologene
    FAMILY
  • glycosyltransferase 2 family
  • GalNAc-T subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the initial step in O-linked (mucin type) oligosaccharide biosynthesis, possessing candidate for synthesis of onconfetal fibronectin
  • responsible for initiating mucin-type O-glycosylation
  • could glycosylate and stabilize an oncoprotein mucin 1 (MUC1), which was upregulated with GALNT6 in breast cancer specimens
  • glycosyltransferase involved in the initial step of O-glycosylation
  • GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
  • Mn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    has transformational potentials through disruptive acinar morphogenesis and cellular changes similar to epithelial-to-mesenchymal transition in normal mammary epithelial cell, MCF10A (
    tumoral     --over  
    might contribute to mammary carcinogenesis through aberrant glycosylation and stabilization of MUC1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    screening of GALNT6 inhibitors would be valuable for the development of novel therapeutic modalities against breast cancer
    ANIMAL & CELL MODELS