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FLASH GENE
Symbol GALNT2 contributors: mct - updated : 10-06-2011
HGNC name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
HGNC id 4124
Location 1q41-q42      Physical location : 230.202.955 - 230.417.875
Synonym name
  • UDP-Gal Nac transferase 2
  • galactosamine:UDP-N-acetyl-alpha-D-polypeptide T2
  • Synonym symbol(s) GALNAC-T2, NAGALT2
    EC.number 2.4.1.41
    DNA
    TYPE functioning gene
    STRUCTURE 214.00 kb     16 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4447 - 571 - 2010 20977886
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    near the N terminus,a stem region,a lumenal catalytic domain containing a GT1 motif and Ga1/Ga1 NAc transferase motif and a C terminal ricin/lectin-like domain,including a QXW lectin repeat
    HOMOLOGY
    interspecies ortholog to bovine Galnact2
    Homologene
    FAMILY GALNAc-transferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the initial reaction in O-linked (mucin type) oligosaccharide biosynthesis
  • mediates the initial step of mucin type-O glycosylation
  • critical mediator of malignant character in hepatocellular carcinoma (HCC) that acts by modifying the activity of the epidermal growth factor receptor (EGFR)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    calcium Ca2+,manganese Mn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS