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FLASH GENE
Symbol GALNT1 contributors: mct - updated : 10-06-2011
HGNC name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
HGNC id 4123
Location 18q12.1      Physical location : 33.234.532 - 33.291.797
Synonym name
  • GalNAc transferase 1
  • protein-UDP acetylgalactosaminyltransferase 1
  • galactosamine:UDP-N-acetyl-alpha-D-polypeptide T1
  • Synonym symbol(s) NAGALT1, GALNAC-T1,
    EC.number 2.4.1.41
    DNA
    TYPE functioning gene
    STRUCTURE 57.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC374864 18q12.1 hypothetical protein LOC374864 LOC147354 18q12.1 similar to additional sex combs like 2; polycomb group protein ASXH2 KIAA1713 18q11 KIAA1713 protein NOL4 18q12 nucleolar protein 4 DTNA 18q12.1-q12.2 dystrobrevin, alpha LOC390849 18 similar to ribosomal protein L10a MAPRE2 18q12 microtubule-associated protein, RP/EB family, member 2 ZNF397 18q12.1 zinc finger protein 397 ZNF271 18q12 zinc finger protein 271 ZNF24 18q12 zinc finger protein 24 (KOX 17) ZNF396 18p12 zinc finger protein 396 LOC125476 18q12.2 hypothetical protein LOC125476 GALNT1 18q12.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) LOC388473 18 LOC388473 PNAS-131 18q12.2 hypothetical protein PNAS-131 P15RS 18q12.2 hypothetical protein FLJ10656 SLC39A6 18q12.2 solute carrier family 39 (zinc transporter), member 6 STATIP1 18q12.1 signal transducer and activator of transcription 3 interacting protein 1 MOCOS 18q12 molybdenum cofactor sulfurase RNU4P3 18q12.2 RNA, U4 small nuclear pseudogene 3 LOC390850 18 similar to RIKEN cDNA 0610008N23 KIAA1695 DKFZP586M1523 KIAA1328 18q12.2 KIAA1328 protein BRUNOL4 18q12 bruno-like 4, RNA binding protein (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    text utilize alternative polyA signals
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3852 - 559 - 2010 20977886
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Endocrineadrenal gland   highly
     thyroid   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialabsorptive excretorydigestive epithelium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal transmembrane domain
  • a stem region
  • a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif
  • a C terminal ricin/lectin-like domain, including a QXW lectin repeat
  • HOMOLOGY
    interspecies homolog to bovine Galnt1
    Homologene
    FAMILY GALNAc-transferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION catalyzing the initial reaction in O-linked (mucin type) oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    manganese Mn2+, calcium Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS