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FLASH GENE
Symbol GALM contributors: mct - updated : 11-10-2010
HGNC name galactose mutarotase (aldose 1-epimerase)
HGNC id 24063
Location 2p22.1      Physical location : 38.893.051 - 38.961.908
Synonym name
  • aldose 1-epimerase
  • galactomutarotase
  • Synonym symbol(s) BLOCK25, IBD1
    EC.number 5.1.3.3
    DNA
    TYPE functioning gene
    STRUCTURE 68.86 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2483 37.8 342 - 2003 12753898
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Galm
    Homologene
    FAMILY
  • aldose epimerase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • a key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose
  • catalyzing the conversion of beta-d-galactose to alpha-d-galactose during normal galactose metabolism
  • catalyzes the interconversion of alpha and beta hexoses, which is essential for normal carbohydrate metabolism and the production of complex oligosaccharides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by all-trans-retinoic acid (RA) (RA is a significant regulator of GALM and other galactose-related genes in myeloid-monocytic cells, which could affect energy utilization and synthesis of cell-surface glycoproteins or glycolipids involved in cell motility, adhesion, and/or functional properties)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS