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FLASH GENE
Symbol GAL3ST1 contributors: mct - updated : 03-09-2010
HGNC name galactose-3-O-sulfotransferase 1
HGNC id 24240
Location 22q12.2      Physical location : 30.950.623 - 30.960.876
Synonym name
  • cerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferase
  • GalCer sulfotransferase
  • 3'- phosphoadenosine-5'phosphosulfate:GalCer sulfotransferase
  • cerebroside sulfotransferase
  • galactosylceramide sulfotransferase
  • Synonym symbol(s) GCST, CST
    EC.number 2.8.2.11
    DNA
    TYPE functioning gene
    STRUCTURE 10.25 kb     4 Exon(s)
    regulatory sequence alternative promoter
    text structure multiple promoters, six alternate 5' untranslated exons 1
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text several alternative initiation sites and usage of untranslated exons
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1791 48.6 423 - Tsuda (2000)
    - - - - - . restricted to stomach and testis Suzuki 2010)
  • also called CST form FTS
  • has a short exon 1f
  • activated by CTCFL
  • promoter contains a potential CTCFL binding site
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  moderately
    Urinarykidneytubule   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Membranemucous membrane   
    cell lineage
    cell lines renal cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two potential N terminal glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Gal3st1 (84.7pc)
    Homologene
    FAMILY
  • galactose-3-O-sulfotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein
    basic FUNCTION
  • catalyzing the sulfation of membrane glycolipids
  • catalyzing the synthesis of galactosylceramide sulfate (the major component of myelin sheat) and monogalactosylalkylacylglycerol sulfate (present in spermatocytes)
  • aberrant usage of transcription initiation sites putatively involved in the cancer associated expression of CST
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    sphingolipid and glycerolipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by enhanced in renal cell carcinoma by EGF,TGF and HGF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    enhanced activity in renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS