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FLASH GENE
Symbol GAGE7 contributors: npt/mct - updated : 06-01-2009
HGNC name G antigen 7
HGNC id 4104
Location Xp11.4-p11.2      Physical location : 49.216.677 - 49.223.937
Synonym name
  • cancer/testis antigen 4.7
  • cancer/testis antigen 4.3
  • G antigen 3
  • Synonym symbol(s) GAGE-7, AL4, CT4.7, GAGE-7B, GAGE-3, CT4.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, head to head
    text GAGE gene locus at chromosome X p11.23 consists of at least 16 genes, each of which is located in one of an equal number of highly conserved tandem repeats, and more genes remain to be identified
    STRUCTURE 7.26 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 498 - 117 - Gjerstorff (2008)
    - - - - - - Cilensek (2002)
    functional link between GAGE7C and two aspects of tumor progression, resistance to Fas induced apoptosis and to chemo- and radio-therapy
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis  highly
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta lowly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three potential casein kinase phosphorylation sites
  • two potential protein kinase C phosphorylation sites
  • one potential N-myristoylation site
  • HOMOLOGY
    interspecies homolog to C.elegans y69a2ar.l
    Homologene
    FAMILY
  • GAGE family of tumor antigen
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION can elicit both cellular and humoral immune responses
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target appropriate targets for cancer immunotherapy
    ANIMAL & CELL MODELS