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FLASH GENE
Symbol GAGE1 contributors: mct/npt - updated : 09-12-2009
HGNC name G antigen 1
HGNC id 4098
Location Xp11.23      Physical location : 49.363.615 - 49.373.139
Synonym name
  • MZ2-F antigen
  • cancer/testis antigen 4.1
  • Synonym symbol(s) CT4.1, MGC33825
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 7.34 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure containing a 143 bp insertion, located in the coding sequence near the termination codon (that is absent from the other of the GAGE family)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC347348 Xp11.23 similar to Heat shock 27 kDa protein (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) JM1 Xp11.23 JM1 protein FOXP3 Xp11.23 forkhead box P3 PPP1R3F Xp11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3F LOC286408 Xp11.23 hypothetical LOC286408 LOC389855 X similar to G antigen 7 GAGE4 Xp11.4-p11.2 G antigen 4 GAGE6 Xp11.4-p11.2 G antigen 6 GAGE7 Xp11.4-p11.2 G antigen 7 GAGE5 Xp11.4-p11.2 G antigen 5 GAGE7B Xp11.2-p11.4 G antigen 7B GAGE2 Xp11.4-p11.2 G antigen 2 GAGE8 Xp11.2-p11.4 G antigen 8 GAGE1 Xp11.4-p11.2 G antigen 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 953 15.5 139 - Gjerstorff (2007)
    5 - 810 13 117 - Gjerstorff (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text in fetal and adult oocyte (Gjerstorff 2007)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • antigenic peptide YRPRPRRY
  • HOMOLOGY
    interspecies homolog to C.elegans r09a8.4
    intraspecies homolog to GAGE family
    Homologene
    FAMILY
  • GAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • recognized on melanoma by autologous cytolytic T lymphocytes
  • might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior (Kong 2004)
  • having a function in germ cells unrelated to any specific developmental stage (Gjerstorff 2007)
  • can elicit both cellular and humoral immune responses, indicating that they are appropriate targets for cancer immunotherapy (Gjerstorff 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular defense response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS