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FLASH GENE
Symbol GADD45GIP1 contributors: shn - updated : 15-03-2017
HGNC name growth arrest and DNA-damage-inducible, gamma interacting protein 1
HGNC id 29996
Location 19p13.13      Physical location : 13.064.972 - 13.068.050
Synonym name
  • CKII beta binding protein 2
  • CKII beta-associating protein
  • CR6 interacting factor 1
  • CR6-interacting factor 1
  • growth arrest and DNA damage-inducible proteins-interacting protein 1
  • p53-responsive gene 6 protein
  • papillomavirus L2 interacting nuclear protein 1
  • papillomavirus L2-interacting nuclear protein 1
  • Synonym symbol(s) PLINP-1, MGC4667, MGC4758, CKBBP2, PRG6, Plinp1, CRIF1
    DNA
    TYPE functioning gene
    STRUCTURE 3.08 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D19S221 - D19S914 - GADD45GIP1 - D19S840 - D19S892 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 744 - 222 - 2015 26210498
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon  
    Endocrineadrenal gland   highly
     thyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland  
    Respiratorylung   highly
     respiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to GADD45GIP1, Pan troglodytes
    ortholog to Gadd45gip1, Rattus norvegicus
    ortholog to Gadd45gip1, Mus musculus
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    basic FUNCTION
  • involved in p53-dependent apoptos
  • involved in the regulation of cell cycle promotion
  • involved in the transactivation of the orphan nuclear receptor Nur77
  • promoting cell proliferation when phosphorylated by CKII
  • acting as a specific transcriptional coactivator of STAT3
  • is a novel and essential transcriptional coactivator of Elf3 for the terminal differentiation of absorptive enterocytes
  • CRIF1 plays likely a critical role in the integration of OXPHOS polypeptides into the mitochondrial membrane in mammals
  • interacting with the large subunit of the mitochondrial ribosome, is indispensable for the mitochondrial translation and membrane insertion of respiratory subunits
  • plays likely a critical role in the maintenance of both mitochondrial structure and respiration in cardiac muscles
  • is a mitochondrial protein essential for the synthesis and formation of the OxPhos complex in the inner mitochondrial membrane
  • plays an important role in maintaining mitochondrial and endothelial function through its effects on the SIRT1-eNOS pathway
  • GADD45GIP1 functions in the nucleus with TP53 and GADD45 family proteins in the suppression of cell growth and tumor development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • interacting with and phosphorylated by CKII Beta subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Gadd45alpha, MyD118/Gadd45beta, and CR6/OIG37/Gadd45gamma
  • orphan nuclear receptor Nur77
  • functions as transcriptional coactivator of ELF3 in intestinal epithelium differentiation
  • NF-E2-related factor 2, NRF2 and regulates its stability
  • GADD45GIP1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of SHC1
  • in a kinase-independent manner, mitochondrial LCK interferes with mitochondrial translational machinery through competitive binding to GADD45GIP1
  • SMARCB1 is indispensable for GADD45GIP1-enhanced TP53 activity and its function in the suppression of cell cycle arrest in human cancer cells
  • cell & other
    REGULATION
    Other downregulated in the apoptotic cells
    negatively regulated by NAC-1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in endothelial cells caused disturbances of mitochondrial oxidative phosphorylation complexes and membrane potential, leading to enhanced mitochondrial reactive oxygen species production
    tumoral        
    GADD45GIP1 silencing promotes leukemic T cell survival in the absence of growth factors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Crif1(beta-/-) mice displayed characteristic ultrastructural mitochondrial abnormalities as well as severe glucose intolerance