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FLASH GENE
Symbol GADD45G contributors: mct - updated : 03-04-2019
HGNC name growth arrest and DNA-damage-inducible, gamma
HGNC id 4097
Location 9q22.2      Physical location : 92.219.926 - 92.221.467
Synonym name
  • DNA damage-inducible transcript 2 protein
  • cytokine response protein 6
  • cytokine-responsive protein CR6
  • gadd-related protein, 17 kD
  • Synonym symbol(s) CR6, GRP17, DDIT2, GADD45gamma
    DNA
    TYPE functioning gene
    STRUCTURE 1.55 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D9S283 - D9S1842 - GADD45G - D9S196 - qter
    Authors Gong (00)
    Physical map
    DAPK1 9q34.1 death-associated protein kinase 1 CTSL 9q21-q22 cathepsin L LOC392360 9 similar to Eukaryotic translation initiation factor 3 subunit 1 (eIF-3 alpha) (eIF3 p35) (eIF3j) LOC392361 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392362 9 similar to fructose-1,6-bisphosphatase 2; fructose-1,6-bisphosphatase isozyme 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase; FBPase; muscle fructose-bisphosphatase; hexosediphosphatase LOC392363 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392364 9 similar to chromosome 15 open reading frame 2 FLJ35866 LOC286235 9q22.2 hypothetical protein LOC286235 CCRK 9q22.2 cell cycle related kinase LOC158104 9q22.2 similar to 40S ribosomal protein S10 LOC389767 9 LOC389767 DKFZP434M131 9q22.1 DKFZP434M131 protein LOC389768 9 similar to potassium channel tetramerisation domain containing 1; chromosome 18 open reading frame 5 LOC389769 9 similar to Laminin receptor 1 SPIN 9q22.1-q22.3 spindlin LOC158046 9q22.2 similar to hypothetical protein BC014127 EDG3 9q22.1-q22.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 SHC3 9q22.1 src homology 2 domain containing transforming protein C3 CKS2 9q22 CDC28 protein kinase regulatory subunit 2 SBP2 9q22.2 SECIS binding protein 2 GADD45G 9q22.1-q22.2 growth arrest and DNA-damage-inducible, gamma LOC389770 9 similar to QCWQ6494 LOC389771 9 LOC389771 LOC157916 9q22.31 interleukin 6 receptor pseudogene LOC392365 9 similar to putative taste receptor HTR2 LOC392366 9 similar to seven transmembrane helix receptor DIRAS2 9q22.32 DIRAS family, GTP-binding RAS-like 2 LOC392367 9 similar to putative taste receptor HTR2 LOC283493 9q22.31 similar to seven transmembrane helix receptor SYK 9q22.1-q22.3 spleen tyrosine kinase AUH 9q22 AU RNA binding protein/enoyl-Coenzyme A hydratase NFIL3 9q22 nuclear factor, interleukin 3 regulated ROR2 9q22.3 receptor tyrosine kinase-like orphan receptor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1087 - 159 - 2016 26521045
    - - 1700 - - liver 2016 26521045
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    nervousbraindiencephalon   
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY ribosomal protein L7AE/gadd45 family
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in negative control of cell growth,DNA repair and/or apoptosis
  • activating MEKK4 and the p38/JNK pathway in response to environmental stress
  • specific role for GADD45G in male fertility and testis development
  • regulates the thermogenic capacity of brown adipose tissue
  • GADD45 family proteins play a crucial role in regulating cellular stress responses and apoptosis
  • plays a critical role in metastasis of prostate and breast cancer cells (PMID
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative control of cell growth noteworthy the pituitary cell proliferation
    PATHWAY
    metabolism
    signaling
  • potential signaling cascade, involving GADD45G &
  • 8594; MAPK14 &
    8594; GATA4 &
    8594; SRY, regulating male sex determination
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediating activation of stress responsive MEKK4,MAPKKK (MAP3Kx)
  • GADD45G is a direct transcriptional target of ASCL1
  • PAX5 was found to be an epigenetically inactivated tumour suppressor that inhibits non-small cell lung cancer (NSCLC) proliferation and metastasis, through down-regulating the CTNNB1 pathway and up-regulating GADD45G expression
  • GADD45A and GADD45G, directly interact with CDK11A and thereby inhibit CDK11A activity, and consequentially SPDEF phosphorylation and degradation, ultimately reducing prostate cancer cell migration and invasion
  • GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MAP2K7) and inhibit its activity, even under normal physiological conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of GADD45G-ZEB2 axis may contribute to cellular senescence evasion and hepatocellular carcinoma (HCC) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate gene for male infertility and 46,XY sex reversal in humans
  • Marker
  • GADD45G suppression is a poor prognostic factor in patients with hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
  • Gadd45g(-/-) XY mice were born as completely sex-reversed XY-females, whereas lack of Gadd45a and/or Gadd45b did not affect primary sex determination or testis development