protein
| mediating activation of stress responsive MEKK4,MAPKKK (MAP3Kx) |
|
GADD45G is a direct transcriptional target of ASCL1 |
|
PAX5 was found to be an epigenetically inactivated tumour suppressor that inhibits non-small cell lung cancer (NSCLC) proliferation and metastasis, through down-regulating the CTNNB1 pathway and up-regulating GADD45G expression |
|
GADD45A and GADD45G, directly interact with CDK11A and thereby inhibit CDK11A activity, and consequentially SPDEF phosphorylation and degradation, ultimately reducing prostate cancer cell migration and invasion |
|
GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MAP2K7) and inhibit its activity, even under normal physiological conditions |