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FLASH GENE
Symbol GABRR2 contributors: - updated : 28-08-2006
HGNC name gamma-aminobutyric acid (GABA) receptor, rho 2
HGNC id 4091
Location 6q14-q16.3      Physical location : 89.967.238 - 90.024.967
Synonym name
  • ionotropic, part of a trimeric receptor
  • DNA
    TYPE functioning gene
    STRUCTURE 57.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   lowly
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemovary  lowly
     male systemprostate  moderately
    Visualeyeretina   
     eye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualbipolar cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 20 aa signal peptide of 2.4 kda
  • a ligand binding site in the N terminal region
  • four transmembrane segments (4TM), one of which forming the wall of the channel
  • a large intracellular loop
  • conjugated GlycoP
    mono polymer heteromer , pentamer
    isoforms Precursor a 445 aa mature peptide of 51.7 kda
    HOMOLOGY
    interspecies ortholog to chimpanzee GABRR2 (99.4pc)
    ortholog to rattus Gabrr2 (91pc)
    ortholog to murine Gabrr2 (87.5pc)
    Homologene
    FAMILY
  • GABAc receptors family
  • ligand-gated ionic channel (TC 1.A.9) family
  • CATEGORY receptor membrane ligand ion channel , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • postsynaptic membrane
  • basic FUNCTION
  • mediating inhibitory neurotransmission
  • may play a role in retinal neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • chloride channel
  • PATHWAY
    metabolism
    signaling neurotransmission , signal transduction , sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
  • protein
  • SQSTM1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS