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FLASH GENE
Symbol GABRR1 contributors: - updated : 25-08-2006
HGNC name gamma-aminobutyric acid (GABA) receptor, rho 1
HGNC id 4090
Location 6q13-q15.3      Physical location : 89.887.222 - 89.927.496
Synonym name ionotropic, part of a trimeric receptor
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  moderately
Lymphoid/Immunethymus    
Reproductivefemale systembreastmammary gland lowly
 female systemplacenta  lowly
Respiratorylung   moderately
Visualeyeretina  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Lymphoid    
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
Visualbipolar cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ligand binding site in the N terminal region
  • four transmembrane segments (4TM), one of which forming the wall of the channel
  • a large intracellular loop
  • conjugated GlycoP
    mono polymer pentamer
    HOMOLOGY
    interspecies ortholog to chimpanzee GABRR1 (94.1pc)
    ortholog to rattus Gabrr1 (94.7pc)
    ortholog to murine Gabrr1 (94.1pc)
    Homologene
    FAMILY
  • GABAc receptors family
  • ligand-gated ionic channel (TC 1.A.9) family
  • CATEGORY receptor membrane ligand ion channel , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • colocalizing with MAP1B
  • postsynaptic membrane
  • basic FUNCTION
  • mediating inhibitory neurotransmission
  • may play a role in retinal neurotransmission
  • involved in synaptic transmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • chloride channel
  • PATHWAY
    metabolism
    signaling neurotransmission , sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
  • protein
  • SQSTM1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS