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FLASH GENE
Symbol GABPB2 contributors: mct - updated : 02-06-2015
HGNC name GA binding protein transcription factor, beta subunit 2
HGNC id 28441
Location 1q21.2      Physical location : 151.043.079 - 151.091.007
Synonym name
  • transcription factor E4TF1-47
  • transcription factor E4TF1-53
  • nuclear respiratory factor 2
  • hypothetical protein MGC29891
  • Synonym symbol(s) MGC29891, E4TF1B, GABPB, GABPB-1, GABPB-2, RP11-68I18.1
    DNA
    TYPE functioning gene
    STRUCTURE 49.33 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1953 48.5 448 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
    Endocrineadrenal gland   highly
    Reproductivefemale systemuteruscervix moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Gabpb2 (85.2 pc)
    homolog to murine Gabpb2 (85.4 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in regulation of transcription
  • GABPB1, GABPB2, GAPBA controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GAPBA (through a DNA binding domain that binds to N-terminal ankyrin-like repeats of GABPB1 and GABPB2)
  • PRKD2 is a functionally significant mediator of the effect of GABPA, GABPB1, GABPB2 on proliferation and apoptosis of BCR-ABL–expressing cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS