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FLASH GENE
Symbol GABPB1 contributors: mct - updated : 02-06-2015
HGNC name GA binding protein transcription factor, beta subunit 1
HGNC id 4074
Location 15q21.2      Physical location : 50.569.389 - 50.647.605
Synonym name
  • nuclear respiratory factor-2 subunit beta
  • adenovirus E4 gene transcription factor-1
  • GA binding protein transcription factor, beta subunit 1, 53kDa
  • GA binding protein transcription factor, beta subunit 2, 47kDa
  • Synonym symbol(s) E4TF1, GABPB, E4TF1-47, E4TF1-53, BABPB2, E4TF1B, GABPB-1, GABPB-2, GABPB2, NRF2B1, NRF2B2
    DNA
    TYPE functioning gene
    STRUCTURE 78.00 kb     12 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D15S123 - D15S119 - D15S126 - GALK2 - DUT - GABPB2 - D15S161 - MYO5A - CYP19A1 - D15S121 - D15S998 - D15S117 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1658 38 360 - Gugneja, Rosmarin (2003)
  • using an alternate in-frame splice site in the 3' coding region compared to variant beta 1
  • 8 splicing 1622 36.8 348 - Gugneja, Rosmarin (2003)
  • containing multiple differences compared to variant beta 1
  • lacking a 12-amino acid serine-rich region compared to isoform beta 1
  • encoding the same protein than variant gamma 3, differing in the 5' UTR
  • 9 splicing 3069 42.4 395 - Gugneja, Rosmarin (2003)
    9 splicing 3033 41.2 383 - Gugneja, Rosmarin (2003)
  • lacking an alternate in-frame segment compared to variant beta 1
  • lacking a 12-amino acid serine-rich region compared to isoform beta 1
  • 9 splicing 1646 36.8 348 - Gugneja
  • containing multiple differences compared to variant beta 1
  • lacking a 12-amino acid serine-rich region compared to variant beta 1
  • encoding the same protein than variant gamma 2, differing in the 5' UTR
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Endocrineneuroendocrinepituitary  moderately
    Lymphoid/Immunelymph node   predominantly
    Reproductivefemale systemuteruscervix moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four tandemly repeated NOTCH motifs at the C terminus
  • a C terminus ETS DNA-binding domain
  • five ankyrin (ANK) repeats
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Gabpb1 (98.6 pc)
    homolog to murine Gabpb1 (98.2 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • putatively involved in the activation of nuclear genes specifying mitochondrial function
  • being necessary for the expression of the Adenovirus E4 gene
  • GABPB1, GABPB2, GAPBA controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with GABPA alpha2/beta2 of an heterotetramer nuclear respiratory factor 2
  • INTERACTION
    DNA interacting with purine rich repeats (GA repeats)
    RNA
    small molecule
    protein
  • GABPA
  • NRF2 (E4F1) regulating STK6
  • recognizing an important site for herpes virus type I activation
  • interacting with HCFC1, causing repression of transcriptional activity
  • binding to GAPBA (through a DNA binding domain that binds to N-terminal ankyrin-like repeats of GABPB1 and GABPB2)
  • PRKD2 is a functionally significant mediator of the effect of GABPA, GABPB1, GABPB2 on proliferation and apoptosis of BCR-ABL–expressing cells
  • SIRT7 is a dynamic nuclear regulator of mitochondrial function through its impact on GABPB1 function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS