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FLASH GENE
Symbol GABARAPL2 contributors: mct/ - updated : 23-03-2016
HGNC name GABA(A) receptor-associated protein-like 2
HGNC id 13291
Location 16q23.1      Physical location : 75.600.248 - 75.611.778
Synonym name
  • ganglioside expression factor 2
  • MAP1 light chain 3 related protein
  • Golgi-associated ATPase enhancer of 16 kDa
  • general protein transport factor p16
  • gamma-aminobutyric acid receptor-associated protein-like 2
  • Synonym symbol(s) GEF2, ATG8, GEF-2, GATE16, GATE-16, FLC3A, ATG8C
    DNA
    TYPE functioning gene
    STRUCTURE 11.53 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1031 13.5 117 - 2014 24269818
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivepancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  predominantly
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
     nerve   moderately
    Reproductivefemale systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    Urinarybladder   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • putative active and nucleotide binding sites
  • a basic N-terminal tubulin binding domain
  • a GABA-A receptor binding domain
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Gabarapl2 (100 pc)
    intraspecies paralog to GABARAPL1
    paralog to GABARAPL3
    Homologene
    FAMILY
  • MAP1LC3 family, GABARAP subfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text autophagic vacuole membrane
    basic FUNCTION
  • involved in intra-Golgi traffic
  • modulating intra-Golgi transport through coupling between NSF activity and SNAREs activation
  • two ubiquitin-like conjugation systems, ATG12 and GABARAPL2 systems, which are tightly associated with expansion of autophagosomal membrane are required for autophagosome formation
  • stimulating the ATPase activity of NSF which in turn stimulates the association with GOSR1
  • GABARAP/GABARAPL2 subfamily is essential for a later stage in autophagosome maturation
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • novel function of GABARAPL2 homologs as a scaffold for signal transduction that regulates autophagosomal maturation
  • GABARAPL2 proteins act as scaffolds for assembly of the ULK complex at the phagophore
  • important role of ATG8 homologues may be to act as a scaffold for the assembly of autophagy complexes
  • macroautophagic sequestration did not require the MAP1LC3 subfamily, but, intriguingly, GABARAP, GABARAPL1, GABARAPL2 are essential
  • GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are not essential for autophagosome formation but are critical for autophagosome-lysosome fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • protein transport
  • intra-Golgi vesicle-mediated transport
  • PATHWAY
    metabolism
    signaling
    A
    a component
  • GABARAP/GABARAPL2 subfamily is essential for a later stage in autophagosome maturation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GABRG2, NSF, GOSR1 and beta-tubulin
  • interacting with ULK1
  • interaction partner of OSBPL7, GABARAPL2 regulates Golgi SNARE of 28kDa (GOSR1) function and stability, and plays a role in autophagosome biogenesis
  • ATG4B is required for processing GABARAPL2 for the latter to be conjugated to phosphatidylethanolamine on autophagosomal membranes, a key step in autophagosome biogenesis (
  • GABARAPL2 targets Atg1/ULK1 to autophagosomes, where it may promote autophagosome maturation and/or fusion with vacuoles/lysosomes
  • ULK1 interacted most strongly with GABARAP and GABARAPL1, but it also interacted with GABARAPL2, MAP1LC3A, and MAP1LC3C
  • partners of CLN8 are VAPA, C14orf1/hERG28, STX8, GABARAPL2, BNIP3 and BNIP3L proteins and are associated with biologically relevant processes such as synthesis and transport of lipids, vesicular/membrane trafficking, autophagy/mitophagy and apoptosis
  • interaction between the human cytosolic family member GIMAP6 and GABARAPL2
  • MCOLN3 and MCOLN3-loop specifically bind to GABARAPL2 and interaction facilitates the function of GABARAPL2 in autophagosome formation, but was not required for MCOLN3 trafficking to autophagosomes
  • MAP1LC3B, GABARAPL2 and GABARAP might play specific roles in different autophagic processes
  • GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy
  • FKBP8 is an GABARAPL1, GABARAPL2-interacting protein
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS