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FLASH GENE
Symbol GABARAPL1 contributors: mct/np - updated : 30-08-2015
HGNC name GABA(A) receptor-associated protein like 1
HGNC id 4068
Location 12p12.3      Physical location : 10.365.488 - 10.375.722
Synonym name
  • early estrogen-regulated protein
  • glandular epithelial cell protein 1
  • gamma-aminobutyric acid receptor-associated protein-like 1
  • APG8-like
  • Synonym symbol(s) GEC1, APG8L, ATG8, ATG8L, ATG8B
    DNA
    TYPE functioning gene
    STRUCTURE 10.24 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC338812 12p13.31 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H box-11 (CHL1-related helicase gene-1); yeast CHL1 homolog LOC347939 12p13.31 similar to Ran-GTP binding protein; RanBP6 LOC390292 12 similar to ovomacroglobulin, ovostatin KLRB1 12p13.1-p12.3 killer cell lectin-like receptor subfamily B, member 1 LOC374443 12p13.31 CLR pseudogene LLT1 12p13 CLR pseudogene LOC387835 12 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 DCAL1 12p13.31 dendritic cell-associated lectin-1 CD69 12p13.2-p13.1 CD69 antigen (p60, early T-cell activation antigen) LOC390293 12 similar to ACRC protein; putative nuclear protein KLRF1 12p13.3-p13.2 killer cell lectin-like receptor subfamily F, member 1 CLECSF2 12p13.2-p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) LOC387836 12 similar to INPE5792 CLL-1 CLEC2 12p13.31 C-type lectin-like receptor-2 LOC387837 12 similar to macrophage antigen h LOC283420 12p13.31 similar to HEEE9341 CLEC1 12p13.31 C-type lectin-like receptor-1 LOC390294 12 similar to HNRPAB protein CLECSF12 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 OLR1 12p13.1-p12.3 oxidised low density lipoprotein (lectin-like) receptor 1 FLJ31166 12p13.31 hypothetical protein FLJ31166 GABARAPL1 12p12.3 GABA(A) receptor-associated protein like 1 KLRD1 12p13.2-p13.1 killer cell lectin-like receptor subfamily D, member 1 KLRK1 12p13.2-p13.1 killer cell lectin-like receptor subfamily K, member 1 KLRC4 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 4 KLRC3 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 3 KLRC2 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 2 KLRC1 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 1 LOC255308 12p13.31 similar to eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2, subunit 3 (gamma, 52kD) KLRA1 12p13.2-p13.1 killer cell lectin-like receptor subfamily A, member 1 FLJ10292 12p13.31 hypothetical protein FLJ10292 DKFZp761P1010 12p13.31 hypothetical protein DKFZp761P1010 CSDA 12p13.1 cold shock domain protein A LOC387838 12 LOC387838 TAS2R7 12p13 taste receptor, type 2, member 7 TAS2R8 12p13 taste receptor, type 2, member 8 TAS2R9 12p13 taste receptor, type 2, member 9 TAS2R10 12p13 taste receptor, type 2, member 10 PROL4 12p13 proline rich 4 (lacrimal) PRH1 12p13.2 proline-rich protein HaeIII subfamily 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1885 14 117 - 2001 11414770
    - - 4200 - - low in ovary, liver peripheral blood leukocytes 2001 11414770
    also called GARAPL1I2
    - - 1700 - - low in placenta 2001 11414770
    also called GARAPLI3
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Nervousbrain   predominantly Homo sapiens
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • N terminal tubulin binding motif
  • HOMOLOGY
    interspecies ortholog to murine Gabarapl1
    ortholog to murine Gabarapl2
    intraspecies homolog to GABARAP
    homolog to GABARAPL2
    homolog to GABARAPL3
    Homologene
    FAMILY
  • microtubule-associated protein (MAP) family, GABARAP subfamaily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons
  • promoting tubulin assembly and microtubule bundling
  • new member of the GABARAP family involved in the transport of GABA(A) receptor
  • could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons
  • with its widespread distribution in the nervous system and its predominantly hydrophobic interactions, may have chaperone-like effects for many cell surface proteins along the biosynthesis pathway
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • displays a complex regulation that is different from that of other GABARAP family members
  • tumor repressor inhibiting WNT signaling via mediating DVL2 degradation through the autophagy pathway
  • important role of ATG8 homologues may be to act as a scaffold for the assembly of autophagy complexes
  • macroautophagic sequestration did not require the MAP1LC3 subfamily, but, intriguingly, GABARAP, GABARAPL1, GABARAPL2 are essential
  • GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are not essential for autophagosome formation but are critical for autophagosome-lysosome fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with tubulin and GABA(A) receptor
  • ATG4B displays increased activity against GABARAPL1
  • interacting with STBD1, and AIM in STBD1 is responsible for its interaction with GABARAPL1
  • HSP90AA1 interacts and protects GABARAPL1 from its degradation by the proteasome
  • strong evidence that transcriptional repression plays a major role in regulating GARAPL1/MAP1LC3A levels, and this up-regulation results in an increase in the size of the autophagosome
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • ULK1 interacted most strongly with GABARAP and GABARAPL1, but it also interacted with GABARAPL2, MAP1LC3A, and MAP1LC3C (pMID: 23043107)
  • GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy
  • FKBP8 is an GABARAPL1, GABARAPL2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS