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FLASH GENE
Symbol G6PC2 contributors: mct - updated : 07-03-2011
HGNC name glucose-6-phosphatase, catalytic, 2
HGNC id 28906
Location 2q31.1      Physical location : 169.757.749 - 169.766.509
Synonym name islet-specific glucose-6-phosphatase catalytic subunit-related protein
Synonym symbol(s) IGRP, MGC141936
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 8.76 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3096 - 355 expressed in the pancreas but not in thymus or spleen 2006 16520917
4 - 2980 - 154 pancreas, thymus , spleen 2006 16520917
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine G6pc2
Homologene
FAMILY PA-phosphatase related phosphoesterase family
CATEGORY enzyme , transport channel
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • may be a single membrane channel protein acting both as a hydrolase and a translocase
  • key enzyme in homeostatic regulation of blood glucose levels
  • may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation
  • Glucokinase (GCK) and G6PC2 regulate the glucose-cycling step in pancreatic beta-cells and may regulate insulin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by endoplasmic reticulum stress (increases glucose-6-phosphatase and glucose cycling in liver cells)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to type 2 diabetes
  • to variation of fasting glucose concentrations
  • Variant & Polymorphism SNP
  • SNPs from G6PC2 associated with type 2 diabetes (G6PC2 genetic variants were associated to both first- and second-phases insulin secretion)
  • significant association between the SNP rs563694 and fasting glucose concentrations
  • Candidate gene G6PC2 inhibitors may be an attractive new approach for the treatment of insulin secretion defects in type 2 diabetes
    Marker
    Therapy target
    ANIMAL & CELL MODELS