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Symbol G3BP2 contributors: mct - updated : 11-12-2012
HGNC name GTPase activating protein (SH3 domain) binding protein 2
HGNC id 30291
Location 4q13.3      Physical location : 76.567.954 - 76.598.667
Synonym name
  • cDNA sequence,putative DNA and RNA helicase,expressed in brain,64kDa,related to murine Ras-GTPase-activating SH3 domain binding protein G3BP
  • Ras-GTPase activating protein SH3 domain-binding protein 2
  • GAP SH3 domain-binding protein 2
  • Synonym symbol(s) KIAA0660, G3BP-2
    DNA
    TYPE functioning gene
    STRUCTURE 30.71 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4410 54 482 - 1996 9575347
    12 - 4275 54 482 - 1996 9575347
    11 - 4311 51 449 - 1996 9575347
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ras-GTPase-activating SH3 domain binding protein G3BP
    Homologene
    FAMILY
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text G3BP2 and PRKCA, relocate to and co-localize in stress granules, but not to P-bodies, when cells are subjected to stress
    basic FUNCTION
  • putative DNA and RNA helicase
  • its arginine methylation appears to be a WNT3A-sensitive 'switch' regulating LRP6 phosphorylation and canonical WNT-CTNNB signaling
  • G3BP1 and G3BP2 play a role in the formation of SGs (stress granules) in various cells and thereby recovery from these cellular stresses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ras-GTPase-activating protein
  • its expression resulted in significant in significant reduction in MDM2-mediated TP53 ubiquitylation and degradation
  • PRKCA binds G3BP2 and regulates stress granule formation following cellular stress
  • cell & other
    REGULATION
    Other methylated in response to WNT3A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS