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FLASH GENE
Symbol G3BP1 contributors: mct - updated : 30-09-2015
HGNC name GTPase activating protein (SH3 domain) binding protein 1
HGNC id 30292
Location 5q33.1      Physical location : 151.151.475 - 151.184.913
Synonym name
  • GAP SH3 domain-binding protein 1
  • Ras-GTPase-activating protein SH3-domain-binding protein
  • ATP-dependent DNA helicase VIII
  • Synonym symbol(s) G3BP, HDH-VIII, MGC111040
    EC.number 3.6.4.12
    DNA
    TYPE functioning gene
    STRUCTURE 33.44 kb     12 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2855 52 466 - 2001 11439350
    12 - 2824 52 466 - 2001 11439350
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouth   highly
    Reproductivefemale systemuteruscervix highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal G3BP contributes to posttranscriptional regulation of cell motility and invasive capacity of pancreatic cancer
  • a NTF2 domain and a RNA recognition motif (RRM)
  • two ribonucleoprotein (RNP) motifs (RNP1 and RNP2)
  • a RG-rich domain and acidic sequences
  • HOMOLOGY
    Homologene
    FAMILY heterogeneous nuclear RNA-binding proteins family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • ATP and Mg2+ dependent DNA/RNA helicase, playing a role in cancer progression
  • scaffolding proteins linking signal transduction to RNA metabolism
  • involved in a phosphorylation-dependent manner, in the post-transcriptional regulation of a subset of mRNAs, at least some of which are in common with those regulated by Hu proteins
  • RNA-binding protein with endoribonuclease activity that is recruited to 'stress granules' after stress stimuli
  • role for G3BP1 in the glycolytic switch that occurs in cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Ras protein signal transduction
    a component
  • USP10/G3BP complex
  • component of stress granules (SGs) that initiates the assembly of SGs by forming a multimer
  • INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding, nucleotide,
  • ATP
  • magnesium Mg2+
  • protein
  • Ras-GTPase-activating protein
  • with USP10 to inhibit the ability of USP10 to disassemble ubiquitin chain
  • HDAC6 interacts with another stress granules protein, G3BP1
  • colocalizes with CAPRIN1 in cytoplasmic RNA granules associated with microtubules (Caprin-1/G3BP1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons and cellular proliferation and migration in multiple cell types)
  • regulator of Ras signalling, and a binding partner of STYXL1
  • SND1 physiologically interact with G3BP1, which is the marker and effector of stress granules
  • direct interaction of the endogenous G3BP1 with ATP5B (interaction of G3BP1 with the 3prime-UTR of beta-F1 mRNA in cytoplasmic RNA-granules)
  • CD24 in stress granules is associated with G3BP1, a phosphorylation-dependent endoribonuclease
  • binds to and degrades Binder of Arl Two (BART, or ARL2BP) mRNA
  • G3BP1 binds and degrades the mRNA of ARL2BP inhibiting retroperitoneal invasion and hepatic metastasis of pancreatic cancer cells
  • marker of cytoplasmic stress granules that are formed in stressed cells and regulate mRNA stability, binds and degrades the mRNA of ARL2BP inhibiting retroperitoneal invasion and hepatic metastasis of pancreatic cancer cells
  • potent stress granules (SG)-nucleating protein G3BP1 is methylated by protein arginine methyltransferase 1 and 5 (PRMT1 and PRMT5)
  • JMJD6 is a novel stress granules component that interacts with G3BP1 complexes, and its expression reduces G3BP1 monomethylation and asymmetric dimethylation at three Arg residues
  • cell & other
    REGULATION
    repressed by CD24 (CD24 inhibits the specific endoribonuclease activity of G3BP1 toward ARL2BP mRNA in stress granules)
    Other regulated by NRG1
    regulated by TARDBP (TARDBP contributes to both the assembly and maintenance of stress granules (SGs)in response to oxidative stress and differentially regulates key SGs components, including TIA1 and G3BP1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer overexpressing ERBB2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS