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FLASH GENE
Symbol FZD9 contributors: mct - updated : 24-08-2011
HGNC name frizzled homolog 9 (Drosophila)
HGNC id 4047
Location 7q11.23      Physical location : 72.848.108 - 72.850.449
Synonym symbol(s) FZD3
DNA
TYPE functioning gene
STRUCTURE 2.34 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - FZD9 - STX1A - [ELN - LIMK1 - RFC2 ] - qter
Authors Wang (97),Osborne (97)
regionally located located in the WBS1 deletion
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2342 - 591 - 1999 10198163
EXPRESSION
Rna function mRNAs expressed specifically in adult spiral ganglion neurons (
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus  
 brainlimbic systemhippocampus   Homo sapiens
Reproductivemale systemtestis   
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • brain, developing neural tube
  • found in the growth cones of adult spiral ganglion neurons
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • receptor consisting of a N terminal cysteine-rich domain, seven transmembrane segments (7TM)
  • one FZD domain for ligand binding
  • a C terminal hydrophilic segment,comprising the S/T-X-X-X-W motif
  • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity gene
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    basic FUNCTION
  • activating Dishevelled
  • exhibiting characteristics of a WNT receptor
  • critical determinant of hippocampal development and is very likely to be a contributing factor to the neurodevelopmental and behavioral phenotype of patients with Williams syndrome
  • receptor of Wnt ligands, playing key roles in liver carcinogenesis
  • having a function in osteoblasts, a finding that may have therapeutic implications for bone loss disorders (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    transmetting WNT signal in brain
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT2 could act through its receptor FZD9 to regulate the CTNNB pathway in cumulus cells, recruiting CTNNB into plasma membranes and promoting the formation of adherens junctions involving CDH1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    FZD9-siRNA could represent a useful therapeutic target for hepatocellular carcinoma (HCC) and hepatoblastoma (HB)
    ANIMAL & CELL MODELS
  • Fzd9(-/-) mice display low bone mass caused by impaired bone formation
  • Frizzled 9-null mice had generally normal gross anatomical hippocampal organization but showed large increases in apoptotic cell death in the developing dentate gyrus