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FLASH GENE
Symbol FZD1 contributors: shn - updated : 22-03-2017
HGNC name frizzled homolog 1 (Drosophila)
HGNC id 4038
Location 7q21.2      Physical location : 90.893.782 - 90.898.131
Synonym name
  • frizzled (Drosophila) homolog 1
  • Wnt receptor
  • frizzled, Drosophila, homolog of, 1
    • Synonym symbol(s) DKFZp564G072, FLJ95923, Fz-1, fzE1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 4.35 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D7S492 - D7S2410 - FZD1 - D7S2409 - D7S1813 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4350 - 647 - -
    EXPRESSION
    Rna function mRNAs expressed specifically in adult spiral ganglion neurons (
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Reproductivefemale systemplacenta  highly
     female systemovary  highly
    Respiratorylung   highly
    Urinarykidney   highly
    cell lineage
    cell lines HL60, HeLa, K562, MOLT-4, Raji, SW480, A549, G361
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cysteine-rich domain
  • seven transmembrane segments (7TM)
  • a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif
    • HOMOLOGY
    interspecies ortholog to Fzd1, Mus musculus
    ortholog to Fzd1, Rattus norvegicus
    ortholog to FZD1, Pan troglodytes
    ortholog to fzd1, Danio rerio
    Homologene
    FAMILY
  • G-protein coupled receptor Fz/Smo family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a receptors for Wnt signaling proteins
  • a functional partner for certain Wnts in inducing TCF dependent transcription
  • involvement of WNT1 and FZD1 in the pathogenesis and development of ALS
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • wingless-type MMTV integration site family member 3A, WNT3A and wingless-type MMTV integration site family member 5A, WNT5A
  • discs, large homolog 4, DLG4
  • lipoprotein receptor-1, LRP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of SOX9, WNT1, FZD1, and Ki-67 proteins occurred more frequently in human osteosarcoma tissues with an advanced clinical stage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS