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FLASH GENE

Symbol

FXYD7

contributors: - updated : 09-03-2006

HGNC name	FXYD domain containing ion transport regulator 7
HGNC id	4034

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.13      Physical location : 35.634.153 - 35.645.205
Synonym symbol(s)	FLJ25096

DNA

TYPE	functioning gene
STRUCTURE	11.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific   brain hindbrain cerebellum       brain limbic system hippocampus

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	core motif of 35 invariant and conserved amino acids
	conserved FXYD motif in the extracytoplasmic domain not involved in the efficient association of FXYD7 with Na,K-ATPase
	C-terminal valine residue involved in the rapid and selective ER export

HOMOLOGY

interspecies	ortholog to murine Fxyd7
	ortholog to rattus fxyd7

Homologene

FAMILY	small membrane proteins family
	FXYD family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	tissue- and isoform-specific Na,K-ATPase regulator which could play an important role in neuronal excitability
	having a particular regulatory function in brain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS