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FLASH GENE
Symbol FXYD5 contributors: - updated : 26-01-2005
HGNC name FXYD domain containing ion transport regulator 5
HGNC id 4029
Location 19q12-q13.1      Physical location : 35.645.624 - 35.660.787
Synonym name
  • dysadherin
  • keratinocytes associated transmembrane protein 1
  • Synonym symbol(s) RIC, IWU1, DYSAD, HSPC113, FXY5, KCT1, OIT2
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a core motif of 35 invariant conserved amino-acid centered on a single transmembrane span
  • 0-glycosylated extracellular domain (Ser-Thr-Pro rich domain)
  • short cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ric
    Homologene
    FAMILY FXYD family
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION involved in tumor progression and metastasis
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CDH1, E-cadherin (down-regulation of E-cadherin)
  • with actin (role in microvilli formation)
  • cell & other
    REGULATION
    induced by by the oncoprotein E2a-Pbx1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS