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FLASH GENE
Symbol FXYD3 contributors: mct/npt - updated : 15/11/2008
HGNC name FXYD domain containing ion transport regulator 3
HGNC id 4027
Location 19q13.11-q13.12      Physical location : 35.606.731 - 35.615.227
Synonym name
  • phospholemman-like protein
  • FXYD domain-containing ion transpor
  • chloride conductance inducer protein Mat-8
  • mammary tumor 8 kDa protein
  • Synonym symbol(s) MAT8, PLML, MAT-8, MGC111076
    DNA
    TYPE functioning gene
    STRUCTURE 8.43 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390919 19 similar to ZNF140-like transcription factor LOC390920 19 similar to zinc finger protein 2 ZNF302 19q13.2 zinc finger protein 302 LOC390921 19 similar to Major allergen I polypeptide chain 1 major form precursor (Allergen Fel d 1-A) (Fel d I-A) (Allergen Cat-1) (Fel dI) (AG4) ZNF181 19q13.1-q13.3 zinc finger protein 181 (HHZ181) FLJ30663 19q13.13 hypothetical protein FLJ30663 LOC390922 19 similar to FLJ38451 protein LOC390923 19 similar to zinc finger protein 113 LOC342885 19q13.13 similar to ABO histo-blood group B transferase DKFZp686N19164 FLJ38451 19q13.13 FLJ38451 protein KIAA1533 19q13.13 KIAA1533 SCN1B 19q13.1 sodium channel, voltage-gated, type I, beta HPN 19q13.1 hepsin (transmembrane protease, serine 1) LOC339320 19q13.13 similar to tectorin alpha precursor; Tectorin, alpha FXYD3 19q13.13 FXYD domain containing ion transport regulator 3 LGI4 19q13.12 leucine-rich repeat LGI family, member 4 FXYD1 19q13.1 FXYD domain containing ion transport regulator 1 (phospholemman) FXYD7 19q13.13 FXYD domain containing ion transport regulator 7 FXYD5 19q12-q13.1 FXYD domain containing ion transport regulator 5 FLJ25660 19q13.13 hypothetical protein FLJ25660 LISCH7 19q13.13 LISCH protein USF2 19q13.1 upstream transcription factor 2, c-fos interacting HAMP 19q13.1 hepcidin antimicrobial peptide MAG 19q13.1 myelin associated glycoprotein FLJ22814 19q13.13 hypothetical protein FLJ22814 CD22 19q13.1 CD22 antigen GPR40 19q13.1 G protein-coupled receptor 40 GPR41 19q13.1 G protein-coupled receptor 41 GPR42 19q13.1 G protein-coupled receptor 42 LOC390924 19 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) GPR43 19q13.1 G protein-coupled receptor 43 LOC388533 19 similar to KIPV467 ZD52F10 19q13.13 hypothetical gene ZD52F10
    RNA
    TRANSCRIPTS type messenger
    text three transcripts : 0,5kb, 2,5kb, 3kb
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1304 - 87 in differentiated cells Arimochi, Bibert (2006)
  • 72p100 sequence identity with mouse FXYD3
  • decreases the apparent K(+) and Na(+) affinity of Na,K-ATPase over a large range of membrane potentials
  • 9 - 1466 - 113 mainly expressed in nondifferentiated cells Arimochi, Bibert (2006)
  • has a 26-amino acid insertion after the transmembrane domain
  • decreases the apparent K(+) affinity only at slightly negative and positive membrane potentials and increases the apparent Na(+) affinity of Na,K-ATPase
  • - - 1588 15 144 - Franzin (2007)
    - - 778 - 96 - Franzin (2007)
    - - 843 - 61 - Franzin (2007)
    - - 759 - 61 - Franzin (2007)
    - - 1466 - 87 - Franzin (2007)
    - - 1460 - 113 - Franzin (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Endocrinepancreas    
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemprostate  highly
    Respiratorylung    
    Urinarybladder   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
     granular cell
    cell lineage
    cell lines breast tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 35 AA signature with the PFXYD motif at the beginning, spanning the membrane
  • a cytoplasmic positively charged C terminus but lacking the phosphorylation sites of FXYD1
  • a cleavable signal peptide
  • HOMOLOGY
    Homologene
    FAMILY
  • FXYD family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be functioning as a chloride channel or as a chloride channel regulator
  • may be involved in the proliferation, differentiation and axon elongation of granules cells as they mature and migrate to the internal granule layer
  • may have been assembled from discrete structural modules through exon shuffling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS