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FLASH GENE

Symbol

FXR2

contributors: npt/mct - updated : 27-09-2017

HGNC name	fragile X mental retardation, autosomal homolog 2
HGNC id	4024

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.1      Physical location : 7.494.547 - 7.518.215
Synonym name	fragile X mental retardation syndrome related protein 2
Synonym symbol(s)	FXR2P, FMR1L2

DNA

TYPE	functioning gene
STRUCTURE	23.52 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D17S675 ,PFN1 - D17S513 - D17S678 ,D17S906 - D17S796 - SLC2A4 - D17S520 - TP53 - cen
Authors	Wilgenbus (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004860 17 - 3016 NP_004851 - 673 - 1997 9259278

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   salivary gland       highly Nervous brain         Reproductive female system uterus cervix   highly   male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	brain, testis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two K homology (KH) domain, and KH2 domains bind kissing complex RNA ligands with the same affinity as the FMR1 KH2 domain although other KH domains do not (Darnell 2009)
	one RGG motif
	a nuclear localization signal (NLS)
	a nuclear export signal (NES)
	putative RNA-binding domains
	a C terminal stretch of basic aminoacids ressembling to nucleolar targeting signal

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Fxr2h

intraspecies

paralog to FXR1, FMR1 (see symbols) (Coffee 2010)

Homologene

FAMILY

FMR1 family

CATEGORY

RNA associated , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	shuttling between cytoplasm and nucleolus

basic FUNCTION	RNA transport and regulation
	may have a role in the development of fragile X mental retardation syndrome
	required for the presence of behavioral circadian rhythms and this role may be relevant to the behavioral alterations observed in fragile X patients
	differential regulation of zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal zones
	FXR2 is important for neuronal dendritic development
	important roles for FXR2 and GRIA1 in neuronal development, and functional convergence between fragile X proteins in this neuronal development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	nucleocytoplasmic transport

PATHWAY

metabolism

signaling

a component

homodimerizing and heterodimerizing with FXR1 and FMR1

INTERACTION

DNA

RNA

binding

small molecule

protein	a nuclear localization signals of FXR1 and also FXR2 with tandem Tudor domain architectures, closely resembling that of UHRF1, which is proposed to bind methylated histone H3K9
	RNA-binding protein FXR2 specifically regulates dentate gyrus (DG) of the hippocampus neurogenesis by reducing the stability of NOG mRNA
	FMR1 and FXR2 additively promote the maturation of new neurons by regulating a common target, the AMPA receptor GRIA1, but via distinct mechanisms
	coordinated regulation of DLG4 mRNA by FMR1 and FXR2 that ultimately affects its fine-tuning during synaptic activity.

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS