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FLASH GENE
Symbol FUT4 contributors: mct - updated : 29-06-2020
HGNC name fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
HGNC id 4015
Location 11q21      Physical location : 94.277.016 - 94.283.062
Synonym name
  • ELAM ligand fucosyltransferase
  • FIM-1 lignad fucosyltransferase
  • Synonym symbol(s) ELFT, FCT3A, CD15, FucT-IV
    EC.number 2.4.1.152
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - TYR - D19S388 - FUT4 - D19S919 - D19S35 - NCAM1 - qter
    Authors Reguigne (94)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2860 46 530 - Taniguchi
    - splicing 2150 - 405 myeloid cell linesúcolon adenocarcinoma cell lines Taniguchi
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage myeloid cells lines
    cell lines colon adenocarnoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Fut4
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • important regulator of inflammatory events
  • may catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1
  • and VIM-2 antigens
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon adenocarcinoma and myeloid cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS