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FLASH GENE
Symbol FUT4 contributors: - updated : 19-12-2005
HGNC name fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
HGNC id 4015
Location 11q21      Physical location : 94.277.016 - 94.283.062
Synonym name
  • ELAM ligand fucosyltransferase
  • FIM-1 lignad fucosyltransferase
  • Synonym symbol(s) ELFT, FCT3A, CD15, FucT-IV
    EC.number 2.4.1.152
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - TYR - D19S388 - FUT4 - D19S919 - D19S35 - NCAM1 - qter
    Authors Reguigne (94)
    Physical map
    LOC341202 11q14.3 similar to Elongation factor 1-alpha 2 (EF-1-alpha-2) (Elongation factor 1 A-2) (eEF1A-2) (Statin S1) MTNR1B 11q21-q22 melatonin receptor 1B SLC36A4 11q14.3 solute carrier family 36 (proton/amino acid symporter), member 4 FLJ25393 11q21 hypothetical protein FLJ25393 FN5 11q13.3-q23.3 FN5 protein LOC390242 11 similar to N6-DNA-methyltransferase isoform 1; N6-DNA-methyltransferase MGC5306 11q21 hypothetical protein MGC5306 PTD012 11q21 PTD012 protein CRSP6 11q14 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa LOC387804 11 LOC387804 LOC341208 11q21 hephaestin-like PANX1 11q21 pannexin 1 LOC387805 11 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) LOC390243 11 similar to folate receptor 3 GPR83 11q21 G protein-coupled receptor 83 MRE11A 11q21 MRE11 meiotic recombination 11 homolog A (S. cerevisiae) FGIF 11q21 fetal globin-inducing factor FUT4 11q21 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) HIWI2 11q21 piwi-like 2 (Drosophila) AMOTL1 11q14.3 angiomotin like 1 LOC390244 11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein HSPC148 11q21 hypothetical protein HSPC148 FLJ10251 LOC390245 11 similar to hypothetical protein FLJ10251 LOC120082 11q21 similar to hypothetical protein FLJ10251 SRP46 11q22 Splicing factor, arginine/serine-rich, 46kD KIAA0830 11q22 Splicing factor, arginine/serine-rich, 46kD SESN3 11q21 sestrin 3 MGC33371 11q21 hypothetical protein MGC33371 KIAA0092 11q22 hypothetical protein MGC33371 MTMR2 11q22 myotubularin related protein 2 MAML2 11q22-q23 mastermind-like 2 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2860 46 530 - Taniguchi
    - splicing 2150 - 405 myeloid cell linesúcolon adenocarcinoma cell lines Taniguchi
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage myeloid cells lines
    cell lines colon adenocarnoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Fut4
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • important regulator of inflammatory events
  • may catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1
  • and VIM-2 antigens
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon adenocarcinoma and myeloid cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS