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FLASH GENE

Symbol

FUT3

contributors: mct/ - updated : 11-06-2020

HGNC name	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
HGNC id	4014

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	LE Lewis blood group
Location	19p13.3      Physical location : 5.842.898 - 5.851.485
Synonym name	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included)
	fucosyltransferase III
	alpha-(1,3/1,4)-fucosyltransferase
Synonym symbol(s)	FCT3A3, FCT4A, CD174, MGC131739, les
EC.number	2.4.1.65

DNA

TYPE	functioning gene
STRUCTURE	14.32 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see FUT6

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000149 3 - 2607 NP_000140 - 361 - 1995 7650030 NM_001097639 3 - 2259 NP_001091108 - 361 - 1995 7650030 NM_001097641 2 - 2066 NP_001091110 - 361 - 1995 7650030 NM_001097640 3 - 2205 NP_001091109 - 361 - 1995 7650030 NM_001382748 3 - 2248 NP_001369677 - 361 - 1995 7650030 NM_001382750 3 - 2194 NP_001369679 - 361 - 1995 7650030 NM_001382749 3 - 2183 NP_001369678 - 361 - 1995 7650030 NM_001382744 3 - 2256 NP_001369673 - 361 - 1995 7650030 NM_001374740 3 - 2198 NP_001361669 - 361 - 1995 7650030 NM_001382745 3 - 2675 NP_001369674 - 361 - 1995 7650030 NM_001382746 3 - 2233 NP_001369675 - 361 - 1995 7650030 NM_001382747 3 - 2214 NP_001091108 - 361 - 1995 7650030

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   intestine small intestine     highly   mouth           salivary gland           stomach       highly Respiratory lung       highly Urinary bladder       lowly   kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	amino acid residue near the amino terminus of the catalytic domain contributing to the acceptor substrate specificity
	a Lys/Arg residue required for catalysis

HOMOLOGY

interspecies

homolog to C.elegans WO3G11.3

Homologene

FAMILY

glycosyltransferase family 10

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type 2 membrane protein

basic FUNCTION	may be involved in blood group lewis determination
	FUT3 is the key enzyme driving sialyl Lewis A (sLe(a)) biosynthesis in human intestinal epithelial cells (IECs)
	selection of mutualistic microorganisms of the intestinal microbiota is controlled by the FUT2 and FUT3 genes that encode fucosyltransferases, enzymes responsible for the synthesis of fucosylated glycan structures of mucins and milk oligosaccharides
	FUT3/FUT6 has an essential role in cancer cell adhesion to endothelial cells by upregulation of sialyl Lewis antigens and also by enhancement of cancer cell migration through TGFB1-mediated EMT

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LE

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   altered expression of fucosylation pathway gene(FUT3), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)

Susceptibility

to intestinal-type gastric cancer

Variant & Polymorphism other	variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer

Candidate gene
Marker	could be useful to predict respectively breast cancer susceptibility
	is a predictive factor for poor overall survival and recurrence free survival in patients with Clear Cell Renal Cell Carcinoma
Therapy target

ANIMAL & CELL MODELS