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FLASH GENE
Symbol FUT3 contributors: mct/ - updated : 07-12-2005
HGNC name fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
HGNC id 4014
Corresponding disease
LE Lewis blood group
Location 19p13.3      Physical location : 5.842.898 - 5.851.485
Synonym name
  • fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included)
  • fucosyltransferase III
  • alpha-(1,3/1,4)-fucosyltransferase
  • Synonym symbol(s) FCT3A3, FCT4A, CD174, MGC131739, les
    EC.number 2.4.1.65
    DNA
    TYPE functioning gene
    STRUCTURE 8.59 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see FUT6
    Physical map
    PTPRS 19p13.3 protein tyrosine phosphatase, receptor type, S LOC388496 19 LOC388496 LOC148066 19p13.3 zinc and ring finger 4 PLAC2 19p13.3 placenta-specific 2 LOC148064 19p13.3 similar to small nuclear ribonucleoprotein E SAFB2 19p13.3 scaffold attachment factor B2 SAFB 19p13.3-p13.2 scaffold attachment factor B LOC125988 19p13.3 hypothetical gene LOC125988 SCDR10 19p13.3 short-chain dehydrogenase/reductase 10 RPL36 19p13.3-p13.2 ribosomal protein L36 PRSS15 19p13.2 protease, serine, 15 MGC39581 19p13.3 hypothetical protein MGC39581 MGC24975 19p13.3 hypothetical protein MGC24975 LOC56931 19p13.3 hypothetical protein from EUROIMAGE 1967720 FUT6 19p13.3 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) NRTN 19p13.3 neurturin FUT3 19p13.3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) FUT5 19p13.3 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) NDUFA11 19p13.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa CAPS 19p13.3 calcyphosine RANBP3 19p13.3 RAN binding protein 3 RFX2 19p13.3 regulatory factor X, 2 (influences HLA class II expression) BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2607 - 361 - -
    3 - 2259 - 361 - -
    2 - 2066 - 361 - -
    3 - 2205 - 361 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     mouth    
     salivary gland    
     stomach   highly
    Respiratorylung   highly
    Urinarybladder   lowly
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • amino acid residue near the amino terminus of the catalytic domain contributing to the acceptor substrate specificity
  • a Lys/Arg residue required for catalysis
  • HOMOLOGY
    interspecies homolog to C.elegans WO3G11.3
    Homologene
    FAMILY
  • glycosyltransferase family 10
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type 2 membrane protein
    basic FUNCTION
  • may be involved in blood group lewis determination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker could be useful to predict respectively breast cancer susceptibility
    Therapy target
    ANIMAL & CELL MODELS