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FLASH GENE
Symbol FUK contributors: mct - updated : 02-01-2019
HGNC name fucokinase
HGNC id 29500
Corresponding disease
CDG1CC congenital disorder of glycosylation, type 1CC
Location 16q22.1      Physical location : 70.488.497 - 70.514.176
Synonym name L-fucose kinase
Synonym symbol(s) FLJ39408, 1110046B12Rik
EC.number 2.7.1.52
DNA
TYPE functioning gene
STRUCTURE 25.68 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D16S3141 - D16S3095 - FUK - D16S3106 - D16S3059 - qter
Authors UCSC (2009)
Physical map
FLJ12331 16q22.1 hypothetical protein FLJ12331 HAS3 16q22.1 hyaluronan synthase 3 FLJ20400 16q22.1 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) CIRH1A 16q22.1 cirrhosis, autosomal recessive 1A (cirhin) SNTB2 16q22-q23 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) VPS4A 16q23.1 vacuolar protein sorting 4A (yeast) COG8 16q22.1 component of oligomeric golgi complex 8 PDF 16q22.1 peptide deformylase-like protein CGI-37 16q22.1 comparative gene identification transcript 37 MGC23911 16q22.1 hypothetical protein MGC23911 TERF2 16q22.1 telomeric repeat binding factor 2 CYB5-M 16q22.1 cytochrome b5 outer mitochondrial membrane precursor NFAT5 16q22.1 nuclear factor of activated T-cells 5, tonicity-responsive NQO1 16q12-q22 NAD(P)H dehydrogenase, quinone 1 NOB1P 16q22.3 likely ortholog of mouse nin one binding protein LOC388285 16 hypothetical gene supported by U89867; NM_007363 WWP2 16q22.1 Nedd-4-like ubiquitin-protein ligase LOC348174 16q22.1 secretory protein LOC348174 LOC390737 16 similar to MGC9515 protein LOC283970 16q22.1 hypothetical protein LOC283970 PDPR 16q22.1 pyruvate dehydrogenase phosphatase regulatory subunit MGC34761 16q22.1 hypothetical protein MGC34761 LOC388286 16 hypothetical gene supported by AF395444; NM_014006 MTR3 16q22.1 homolog of yeast mRNA transport regulator 3 AARS 16q22.1 alanyl-tRNA synthetase DDX19 16q22.1 DEAD (Asp-Glu-Ala-As) box polypeptide 19 FLJ11126 16q22.1 hypothetical protein FLJ11126 SIAT4B 16q22.3 sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase) FUK 16q22.1 fucokinase COG4 16q22.3 component of oligomeric golgi complex 4 SF3B3 16q22.1 splicing factor 3b, subunit 3, 130kDa MGC34647 16q22.1 hypothetical protein MGC34647 LOC92154 16q22.1 hypothetical protein BC002770 FLJ10305 16q22.1 hypothetical protein FLJ10305 HYDIN 16q22.2 hydrocephalus inducing LOC388287 16 similar to hydrocephalus-inducing protein FLJ14665 16q22.2 hypothetical protein FLJ14665 DKFZp434L0850 16q22.2 hypothetical protein DKFZp434L0850 FLJ11171 16q22.2 hypothetical protein FLJ11171 LOC388288 16 similar to hypothetical protein (L1H 3 region) - human CALB2 16q22.2 calbindin 2, 29kDa (calretinin) ZNF23 16q22.2 zinc finger protein 23 (KOX 16) LOC390738 16 similar to mKIAA1261 protein ZNF19 16q23.1 zinc finger protein 19 (KOX 12) CHST4 16q23.1 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 TAT 16q22.1 tyrosine aminotransferase LOC91862 16q22.2 similar to RIKEN cDNA 1810006A16 gene KIAA0931 16q23.1 similar to RIKEN cDNA 1810006A16 gene AP1G1 16q23 adaptor-related protein complex 1, gamma 1 subunit LOC342371 16q22.2 similar to Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) LOC55565 16q22.2 hypothetical protein LOC55565 KIAA0174 16q23.1 hypothetical protein LOC55565 PKD1L3 16q22.2 polycystic kidney disease 1-like 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 3923 117.5 1084 - 2002 12056818
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
Visualeyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Fuk (85.8 pc)
homolog to rattus Fuk (85.6 pc)
Homologene
FAMILY
  • galacto-, homoserine, mevalonate and phosphomevalonate (GHMP) kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • taking part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides (Hinderlich 2002)
  • catalyzing the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate
  • only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1CC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS