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FLASH GENE
Symbol FUCA1 contributors: mct/npt - updated : 18-06-2010
HGNC name fucosidase, alpha-L- 1, tissue
HGNC id 4006
Corresponding disease
FUCA1D fucosidosis
Location 1p36.11      Physical location : 24.171.573 - 24.194.859
Synonym name Nbla10230/alpha-L-fucosidase
Synonym symbol(s) FUCA
EC.number 3.2.1.51
DNA
TYPE functioning gene
STRUCTURE 23.25 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
C1QA 1p36.3-p34.1 complement component 1, q subcomponent, alpha polypeptide C1QG 1p36.3-p34.1 complement component 1, q subcomponent, gamma polypeptide C1QB 1p36.11 complement component 1, q subcomponent, beta polypeptide EPHB2 1p36.1-p35 EphB2 LOC127309 1p36.11 similar to RIKEN cDNA 4930549C01 KIAA0601 1p36.11 KIAA0601 protein LUZP1 1p36 leucine zipper protein 1 LOC391018 1 similar to RIKEN cDNA 2410002F23 HTR1D 1p35 5-hydroxytryptamine (serotonin) receptor 1D LOC391019 1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) HNRPR 1p36.11 heterogeneous nuclear ribonucleoprotein R ZNF436 1p36 zinc finger protein 436 TCEA3 1p36.11 transcription elongation factor A (SII), 3 UPLC1 1p36.11 up-regulated in liver cancer 1 E2F2 1p36.11 E2F transcription factor 2 ID3 1p36.13-36.12 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein AD7C-NTP 1p36 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein RPL11 1p36.1-p35 ribosomal protein L11 TCEB3 1p36.1 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) HT014 1p36.11 HT014 LYPLA2 1p36.12-p35.1 lysophospholipase II GALE 1p36-p35 galactose-4-epimerase, UDP- HMGCL 1p36.11 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) FUCA1 1p36.1 fucosidase, alpha-L- 1, tissue FLJ35961 1p36.11 hypothetical protein FLJ35961 IL22RA1 1p36.11 interleukin 22 receptor, alpha 1 IL28RA 1p36.11 interleukin 28 receptor, alpha (interferon, lambda receptor) SOM 1p36.11 sister-of-mammalian grainyhead LOC90529 1p36.11 hypothetical protein LOC90529 DJ462O23.2 1p36.12-p35.1 hypothetical protein dJ462O23.2 DSCR1L2 1p35.3-p33 Down syndrome critical region gene 1-like 2 SRRM1 1p36.11 serine/arginine repetitive matrix 1 CLIC4 1p36.11 chloride intracellular channel 4 RUNX3 1p36.11 runt-related transcription factor 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2133 - 466 - Venditti (2007)
- - - - - sperm Venditti (2007)
  • also called FUCA1SP
  • membrane-associated isozyme of human sperm cells
    		•
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Fuca (80.54 pc)
    homolog to murine Fuca1 (83.96 pc)
    Homologene
    FAMILY
  • glycosyl hydrolase 29 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins
  • has a role in the intimate species signature interactions between sperm and oocyte (Vendetti 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) FUCA1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS