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FLASH GENE
Symbol FSTL3 contributors: mct - updated : 28-09-2011
HGNC name follistatin-like 3 (secreted glycoprotein)
HGNC id 3973
Corresponding disease
FSTL3 B cell chronic leukemia
Location 19p13.3      Physical location : 676.388 - 683.392
Synonym name
  • follistatin-related protein 3
  • follistatin-related gene protein
  • Synonym symbol(s) FLRG, FSRP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, head to head
    STRUCTURE 7.04 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif
    text structure four 107-108 bp evolutionary conserved repeats containing one functionally active NFKB1 binding element, and TNF-responsive elements
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390871 19 similar to CXYorf1-related protein LOC390872 19 similar to Olfactory receptor 4F3 LOC388486 19 similar to bA476I15.3 (novel protein similar to septin) LOC390873 19 similar to capicua homolog LOC388487 19 LOC388487 PPAP2C 19p13 phosphatidic acid phosphatase type 2C KIAA1193 19p13.3 phosphatidic acid phosphatase type 2C THEG 19p13.3 Theg homolog (mouse) KIAA1957 19p13.3 KIAA1957 FLJ40059 19p13.3 hypothetical protein FLJ40059 MADCAM1 19p13.3 mucosal vascular addressin cell adhesion molecule 1 LOC91978 19p13.3 hypothetical gene supported by BC009520 CDC34 19p13.3 cell division cycle 34 GZMM 19p13.3 granzyme M (lymphocyte met-ase 1) BSG 19p13.3 basigin (OK blood group) HCN2 19p13.3 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 POLRMT 19p13.3 polymerase (RNA) mitochondrial (DNA directed) FGF22 19p13.3 fibroblast growth factor 22 RNF126 19p13.3 ring finger protein 126 FSTL3 19p13 follistatin-like 3 (secreted glycoprotein) PALM 19p13.3 paralemmin LOC126353 19p13.3 hypothetical protein LOC126353 PTBP1 19p13.3 polypyrimidine tract binding protein 1 FLJ11535 19p13.3 hypothetical protein FLJ11535 AZU1 19p13.3 azurocidin 1 (cationic antimicrobial protein 37) PRTN3 19p13.3 proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) ELA2 19p13.3 elastase 2, neutrophil DF 19p13.3 D component of complement (adipsin) TRAP95 MGC16353 19p13.3 hypothetical protein MGC16353 GPR54 19p13.3 G protein-coupled receptor 54 DRIL1 19p13.3 dead ringer-like 1 (Drosophila) WDR18 19p13.3 WD repeat domain 18 GRIN3B 19p13.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B C19orf6 19p13.3 chromosome 19 open reading frame 6 CNN2 21q11 calponin 2 ABCA7 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 HA-1 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 POLR2E 19p13.3 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa GPX4 19p13.3 glutathione peroxidase 4 (phospholipid hydroperoxidase) KIAA0963 19p13.3 Homo sapiens KIAA0963 protein (KIAA0963), mRNA. STK11 19p13.3 serine/threonine kinase 11 (Peutz-Jeghers syndrome) MGC40084 19p13.3 hypothetical protein MGC40084 ATP5D 19p13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2525 27.7 263 - 1998 9799587
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Endocrineadrenal gland   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemovary  highly
     female systemplacenta  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumcardiac   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    Cardiovascularendothelial cell Homo sapiens
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, amniocytes, chorionic villosities
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain (ND) of FSTL3 interacts uniquely with MSTN as compared with activin A, because it utilizes different surfaces on the ligand
  • two cysteine-rich repeats closely related to class 1-1 follistatin modules
  • two kazal-like domains
  • two potential N-glycosylation sites
  • two FSDs (follistatin domains), but lacks a cell surface heparin-binding motif located in FSD1 of FSL
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Fstl3
    Homologene
    FAMILY
  • follistatin-module-protein family
  • CATEGORY regulatory , secretory , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in leukemogenesis
  • inhibiting activin A signaling
  • playing a role through regulation of activin and myostatin in normal adult metabolic homeostasis
  • may contribute to bone formation by inhibiting osteoclast differentiation from hematopoietic precursors
  • stress-induced regulator of hypertrophy that controls myocyte size via regulation of SMAD signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text negative feedback loop regulating activin activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to activin and BMP-2
  • direct target gene of the SMAD proteins in response to TGFB
  • interaction of the N-terminal domain of FSTL3 with activin A (extracellular regulator of activin A protein)
  • myostatin interacts with its inhibitor, follistatin-like-3 (FSTL3)
  • MSTN is tightly controlled by Fst-like 3 (FSTL3), which is the only FST-type molecule that has been identified in the serum bound to myostatin
  • cell & other
    REGULATION
    activated by at the transcriptional level by TNF and NFKB1
    induced by TGFB through the activin of SMADS (MADHs) proteins
    with Activin A are induced in heart by myocardial stress
    Other differently regulated in ovarian granulosa-luteal cells by protein kinase C and A
    ASSOCIATED DISORDERS
    corresponding disease(s) FSTL3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation --other  
    aberrantly expressed in B cell chronic leukemia and a translocation t(11;19)(q13;p13)
    constitutional     --low  
    first-trimester FSTL3 low levels are associated with glucose intolerance and gestational diabetes mellitus later in pregnancy
    constitutional     --over  
    with FSTL1 in heart failure but returned to normal after recovery
    tumoral     --over  
    increased FST and FSTL3 expression in breast proliferative diseases might counteract the anti-proliferative effects of activin in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target reduced FSTL3 activity (FSTL3 antagonists or activin) might simultaneously reduce visceral adiposity, increase beta cell mass, and improve insulin sensitivity
    SystemTypeDisorderPubmed
    obesity  
    reduced FSTL3 activity (FSTL3 antagonists or activin) might simultaneously reduce visceral adiposity, increase beta cell mass, and improve insulin sensitivity
    ANIMAL & CELL MODELS