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FLASH GENE
Symbol FSIP1 contributors: mct - updated : 05-06-2020
HGNC name fibrous sheath interacting protein 1
HGNC id 21674
Location 15q14      Physical location : 39.892.233 - 40.075.039
Synonym symbol(s) HSD10, FLJ35989
DNA
TYPE functioning gene
STRUCTURE 185.56 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2816 - 581 - 2020 31713931
12 - 2719 - 581 - 2020 31713931
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivefemale systembreastmammary gland  
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Fsip11
ortholog to dog LOC4782561
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • unique cytoskeletal structure located in the principal piece of the sperm flagellum
  • testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells
  • is a component of the microtubule- and dynein-rich fibrous sheath structure, which is essential for flagellum function and sperm movement
  • overexpression of NXF2, FSIP1, and STARD6, in the absence of paclitaxel, increased the generation of multinucleated cells, a hallmark of aberrant mitosis
  • role of FSIP1 as well as mechanisms underlying FSIP1 action in drug sensitivity in breast cancer
  • regulates autophagy in breast cancer
  • FSIP1 has a crucial role in hormone receptor (HR)-positive breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding AKAP3, AKAP4, and FSIP2
  • FSIP1 binds to ULK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancers, particularly in those overexpressing human epidermal growth factor receptor 2 (ERRB2)
    tumoral     --over  
    FSIP1 overexpression showed good correlation with tumor stage and lymph node metastasis in bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • represents a predictive target for bladder cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may become a potential target for breast cancer therapy
    cancerreproductivebreast
    represents an attractive therapeutic target for HR-positive breast cancer
    cancerurinary 
    potential therapeutic or
    ANIMAL & CELL MODELS