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FLASH GENE
Symbol FSD1 contributors: - updated : 24-03-2004
HGNC name fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1
HGNC id 13745
Location 19p13.3      Physical location : 4.304.590 - 4.323.843
Synonym symbol(s) MGC3213, MIR1
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TJP3 19p13.3 tight junction protein 3 (zona occludens 3) APBA3 19p13.3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) MRPL54 19p13.3 mitochondrial ribosomal protein L54 MGC15631 19p13.3 hypothetical protein MGC15631 MATK 19p13.3 megakaryocyte-associated tyrosine kinase KIAA1086 19p13.3 megakaryocyte-associated tyrosine kinase LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981 EBI3 19p13.3 Epstein-Barr virus induced gene 3 FLJ10374 19p13.3 hypothetical protein FLJ10374 SHD 19p13.3 src homology 2 domain-containing transforming protein D MGC23244 19p13.3 hypothetical protein MGC23244 FSD1 19p13.3 fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1 STAP2 19p13.3 signal-transducing adaptor protein-2 FLJ14981 19p13.3 hypothetical protein FLJ14981 SH3GL1 19p13.3 SH3-domain GRB2-like 1 CHAF1A 19p13.3 chromatin assembly factor 1, subunit A (p150) UBXD1 19p13 UBX domain containing 1 MGC2641 19p13.3 hepatoma-derived growth factor-related protein 2 FLJ20700 19p13.3 hypothetical protein FLJ20700 LOC388495 19 similar to Calphotin CG4795-PA LRG SEMA6B 19p13.3 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B MGC17791 19p13.3 hypothetical protein MGC17791 C19orf10 19p13.3 chromosome 19 open reading frame 10 DPP9 19p13.3 dipeptidylpeptidase 9 PGSF1 19p13.3 pituitary gland specific factor 1a FEM1A 19p13.3 fem-1 homolog a (C.elegans)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Nervousbrain   highly
nervousbraindiencephalon   
Reproductivemale systemtestis   
cell lineage
cell lines fibrosarcoma, osteosarcoma
fluid/secretion
at STAGE
physiological period fetal
Text brain, thymus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil region
  • a fibronectin type III domain
  • a SPRY domain
  • conjugated GlycoP
    mono polymer homomer , dimer , trimer
    HOMOLOGY
    interspecies ortholog to murine Fsd1
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text FSD1 dissociates from centrosomes at the G2/M transition nad is recruited back to spindle poles during anaphase (cell-cycle dependent association)
    basic FUNCTION microtubule-binding activity
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by phosphorylation by cdk5/p35
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS