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FLASH GENE
Symbol FSCN3 contributors: - updated : 21-04-2007
HGNC name fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
HGNC id 3961
Location 7q31.3      Physical location : 127.233.688 - 127.241.843
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GRM8 7q31.3-q32.1 glutamate receptor, metabotropic 8 LOC346646 7q32.2 similar to Protein C20orf45 (CGI-107) LOC168850 7q32.2 hypothetical protein LOC168850 GCC1 7q22.3 golgi coiled-coil 1 ARF5 7q31.3 ADP-ribosylation factor 5 FSCN3 7q31.3 fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus) PAX4 7q32 paired box gene 4 SND1 7q31.3 paired box gene 4 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4 LEP 7q31.3 leptin (obesity homolog, mouse) MGC27345 7q32.2 hypothetical protein MGC27345 FLJ10377 7q32.2 hypothetical protein FLJ10377 LOC389551 7 hypothetical gene supported by BC063892 IMPDH1 7q31.3-q32 IMP (inosine monophosphate) dehydrogenase 1 HIG2 7q32.2 hypoxia-inducible protein 2 METTL2 17q24.1 methyltransferase like 2 LOC389552 7 similar to Serine/threonine-protein kinase tousled-like 2 (Tousled-like kinase 2) (PKU-alpha) LOC389553 7 hypothetical gene supported by AL137733 LOC389554 7 hypothetical gene supported by BC062355 LOC392095 7 similar to capicua homolog LOC346653 7q32.2 hypothetical protein LOC346653 NYD-SP18 7q32.2-q32.3 testes development-related NYD-SP18 CALU 7q32 calumenin
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
 male systemtestis  specific
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fascin domains
  • C terminal half actin-binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila singed gene
    homolog to sea urchin
    Homologene
    FAMILY actin-bundling protein fascin, paralog family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text expressed in elongating spermatid
    basic FUNCTION
  • may function in the terminalelongation of spermatid head and šin microfilament rearrangements that accompany feryilization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS