Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | FRZB | contributors: MCT - updated : 14-12-2018 |
HGNC name | frizzled-related protein |
HGNC id | 3959 |
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Location | 2q32.1 Physical location : 183.698.004 - 183.731.498 |
Synonym name | |
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Synonym symbol(s) | FZDS3, SFRP3, FRZB1, FRE, FZRB, hFIZ, FRITZ, FRP3, FRZB-PEN, SRFP3 |
DNA |
TYPE | functioning gene |
STRUCTURE | 33.50 kb 6 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | embryo, fetal |
Text | cartilage of long bones appendicular skeleton, epiphysis, muscle, kidney, pancreas, heart |
PROTEIN |
PHYSICAL PROPERTIES | Hydrophilic | |
STRUCTURE |
motifs/domains
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HOMOLOGY |
interspecies | homolog to Drosophila frizzled polarity |
homolog to rattus Frzb (91.33 pc) | |
homolog to murine Frzb (91.95 pc) |
Homologene |
FAMILY | SFRP family of WNT inhibitors family |
CATEGORY | tumor suppressor , signaling |
SUBCELLULAR LOCALIZATION | extracellular |
| plasma membrane |
| intracellular |
intracellular,cytoplasm |
basic FUNCTION | |
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CELLULAR PROCESS
| cell life |
PHYSIOLOGICAL PROCESS | development , ossification |
text | bone development, maintenance |
PATHWAY |
metabolism |
signaling |
COL6A1, COL6A2, CRELD1, FBLN2, FRZB, and GATA5 harboring purportedly deleterious case-specific variants in atrioventricular septal defects (AVSD)are associated in some way with VEGFA ![]() |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | ![]() |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
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Variant & Polymorphism | Arg200Trp and Arg324Gly increasing the risk factor for primary hip osteoarthritis in the female |
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |