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FLASH GENE
Symbol FRYL contributors: mct - updated : 06-03-2019
HGNC name FRY-like
HGNC id 29127
Location 4p12      Physical location : 48.499.379 - 48.782.316
Synonym name
  • hypothetical protein LOC23045
  • furry homolog-like (Drosophila)
  • Synonym symbol(s) KIAA0826, FLJ16177, AF4p12
    DNA
    TYPE functioning gene
    STRUCTURE 36.00 kb     5 Exon(s)
    MAPPING cloned N linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal part fused to MLL with a leucine zipper motif and exhibiting transcriptional activation properties when fused to GAL4 DNA-binding domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • MLL fusion partner
  • important function for FRYL in NOTCH1-mediated transcriptional activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acts as a NOTCH1 coactivator and plays a role in transcriptional activation events subsequent to ICN1 (intracellular active form of NOTCH1) recruitment that are required for RNAPII assembly at several NOTCH1-responsive loci
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in lymphoid leukemia, with t(4;11)(p12;q23) resulting in the creation of a chimeric RNA encoding a putative fusion protein containing 1,362 amino acids from the NH2-terminal part of MLL and 712 amino acids from the COOH-terminal part of FRYL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS