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FLASH GENE
Symbol FRY contributors: mct/ - updated : 08-10-2015
HGNC name furry homolog (Drosophila)
HGNC id 20367
Location 13q13.1      Physical location : 32.605.436 - 32.870.775
Synonym name chromosome 13 open reading frame 14
Synonym symbol(s) C13orf14, 13CDNA73, CG003, bA37E23.1, WUGSC:H_2G3A.1, 214K23.2
DNA
TYPE functioning gene
STRUCTURE 265.34 kb     61 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
61 - 10718 300 3013 - 2012 22753416
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus    
Endocrinepancreas    
Hearing/Equilibriumear    
Lymphoid/Immunethymus    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • HEAT/Armadillo-like repeats near the N terminus, and expression of the N-terminal fragment of FRY induced hyperacetylation of MTs in both mitotic and interphase cells
    • HOMOLOGY
    interspecies homolog to murine Fry (95.9pc)
    Homologene
    FAMILY
  • furry protein family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • binds to microtubules, localizes on the spindle
  • localizes to centrosomes and spindle microtubules in early mitosis
  • distributed diffusely throughout the cytoplasm in interphase but localized to the separating centrosomes in prophase, to the spindle poles and spindle MTs in prometaphase to metaphase, to spindle MTs in anaphase, and to the distal sections of the midbody in cytokinesis
    • basic FUNCTION
  • binds to microtubules, localizes on the spindle, acts as a scaffold that binds to both STK38 and MOB2, and synergistically activates STK38 with MOB2
  • STK3-, FRY-, and MOB2-mediated activation of STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells
  • evolutionarily conserved protein implicated in cell division and morphology
  • plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis
  • plays a crucial role in PLK1 activation in early mitosis
  • plays a crucial role in spindle pole integrity by promoting PLK1 activity on centrosomes in early mitosis
  • evolutionarily conserved protein that binds to MTs (microtubules) and colocalizes with acetylated MTs in the mitotic spindle
  • plays a crucial role in promoting the level of MT acetylation in the mitotic spindle by inhibiting the tubulin-deacetylase activity of SIRT2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to PLK1 and AURKA and promotes AURKA-mediated PLK1 activation
  • mitotic FRY, but not interphase FRY, has the potential to bind to PLK1
  • binds to the tubulin deacetylase SIRT2, preferentially in mitotic cells
    • cell & other
    REGULATION
    Phosphorylated by PLK1 that phosphorylates the C-terminal region of FRY
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    causes chromosome misalignment and multipolar spindle formation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS