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FLASH GENE
Symbol FRS3 contributors: mct/npt - updated : 05-04-2008
HGNC name fibroblast growth factor receptor substrate 3
HGNC id 16970
Location 6p21.1      Physical location : 41.737.913 - 41.747.630
Synonym name
  • suc1-associated neurotrophic factor target 2 (FGFR signaling adaptor)
  • FRS2-beta
  • FGFR substrate 3
  • Synonym symbol(s) SNT2, FRS2B, FRS2beta, MGC17167, SNT-2, FRS-3
    DNA
    TYPE functioning gene
    STRUCTURE 9.72 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    UNC5CL 6p21.1 unc-5 homolog C (C. elegans)-like BZRPL1 6p21.1 benzodiazapine receptor (peripheral)-like 1 APOBEC2 6p21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 C6orf130 6p21.1 chromosome 6 open reading frame 130 NFYA 6p21.3 nuclear transcription factor Y, alpha LOC221442 6p21.1 hypothetical protein LOC221442 TREML1 6p21.1 triggering receptor expressed on myeloid cells-like 1 TREM2 6p21.1 triggering receptor expressed on myeloid cells 2 C6orf76 6p21.1 chromosome 6 open reading frame 76 LOC285852 6p21.1 hypothetical protein LOC285852 TREM1 6p21.1 triggering receptor expressed on myeloid cells 1 NCR2 6p21.1 natural cytotoxicity triggering receptor 2 FOXP4 6p21.1 forkhead box P4 MDFI 6p21 MyoD family inhibitor TFEB 6p21 transcription factor EB PGC 6p22-p12 progastricsin (pepsinogen C) FRS3 6p21.1 fibroblast growth factor receptor substrate 3 C6orf49 6p21.31 chromosome 6 open reading frame 49 MGC20741 6p21 ubiquitin specific protease 49 USP49 6p12.1 ubiquitin specific protease 49 BYSL 6p21.1 bystin-like CCND3 6p21 cyclin D3 TBN 6p21.1 taube nuss homolog (mouse) LOC389389 6 similar to hypothetical protein BC006605 GUCA1A 6p21.1 guanylate cyclase activator 1A (retina) GUCA1B 6p21.1 guanylate cyclase activator 1B (retina) MRPS10 6p21.1-p12.1 mitochondrial ribosomal protein S10 TRERF1 6p21.1-p12.1 transcriptional regulating factor 1 C6orf133 6p21.1 chromosome 6 open reading frame 133
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2200 54.3 492 - Huang (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Lymphoid/Immunespleen    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal myristylation sites for localization to membranes, including the plasma membrane
  • a phosphotyrosine binding (PTB) domain for binding to RTKs, such as the fibroblast growth factor (FGF) receptor and neurotrophin receptor (Minegishi 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • DOK family
  • fibroblast growth factor receptor substrate (FRS)-2 family proteins
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • docking proteins interacting with receptor tyrosine kinases and mediating particular biological responses
  • may be playing a role in the intracellular degradation systems of neural cells, which involves lysosomes (Minegishi 2009)
  • unique scaffolding adaptor that serves as a negative as well as a positive regulator for RTK signaling, depending on the receptor species (Minegishi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RASA1, TEK receptor and EGF receptor
  • binds all neurotrophin TRK receptor tyrosine kinases and becomes tyrosine phosphorylated in response to NGF, BDNF, NT-3
  • binding GRB2 and SHP2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS