basic FUNCTION
| functioning as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation |
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playing a role in the induction of lens and retina through recruitment of FGF and PTPN11 |
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plays a pivotal role in FGF-dependent activation of the Ras-MAP kinase, PI-3 kinase, and FRAP1 pathways in breast carcinoma cells |
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central mediator in FGF signaling (Minegishi 2009) |
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FGF/FRS2& |
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945;-mediated signals prevent premature differentiation of heart progenitor cells through suppressing autophagy. |
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is an adaptor protein that plays a critical role in FGFR signaling |
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FRS2-PTPN11 complex is the key mediator of FGF signaling in lens development |
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is a previously unidentified component of VEGF receptors signaling |
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FRS2 signaling is critical for nephron progenitors |
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is an FGF receptor-associated protein required for activation of downstream signaling molecules that include those in the mitogen-activated protein and AKT1 kinase pathways |
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FRS2, FRS3 may act as an important node for FGF and neurotrophin signaling in postnatal hippocampal development |