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FLASH GENE
Symbol FRS2 contributors: mct/npt - updated : 02-10-2018
HGNC name fibroblast growth factor receptor substrate 2
HGNC id 16971
Location 12q15      Physical location : 69.864.128 - 69.973.561
Synonym name suc1-associated neurotrophic factor target (FGFR signalling adaptor)
Synonym symbol(s) SNT, SNT1, FRS2A, SNT-1, FRS2alpha
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 109.44 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390341 12 similar to nuclear localization signal containing protein deleted in Velo-Cardio-Facial syndrome DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R TM4SF3 12q14.1-q21.1 transmembrane 4 superfamily member 3 GPR49 12q22-q23 G protein-coupled receptor 49
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 6883 - 508 - 2017 28077787
10 - 6876 - 508 - 2017 28077787
10 - 6911 - 508 - 2017 28077787
11 - 6997 - 508 - 2017 28077787
10 - 6929 - 508 - 2017 28077787
11 - 6940 - 508 - 2017 28077787
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinaryureter     Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier lininguroepithelium   Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal myristylation sites for localization to membranes, including the plasma membrane
  • a phosphotyrosine binding (PTB) domain for binding to RTKs, such as the fibroblast growth factor (FGF) receptor and neurotrophin receptor
  • four potential GRB2-binding sites
  • HOMOLOGY
    intraspecies homolog to FRS3
    Homologene
    FAMILY
    CATEGORY adaptor , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functioning as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation
  • playing a role in the induction of lens and retina through recruitment of FGF and PTPN11
  • plays a pivotal role in FGF-dependent activation of the Ras-MAP kinase, PI-3 kinase, and FRAP1 pathways in breast carcinoma cells
  • central mediator in FGF signaling (Minegishi 2009)
  • FGF/FRS2&
  • 945;-mediated signals prevent premature differentiation of heart progenitor cells through suppressing autophagy.
  • is an adaptor protein that plays a critical role in FGFR signaling
  • FRS2-PTPN11 complex is the key mediator of FGF signaling in lens development
  • is a previously unidentified component of VEGF receptors signaling
  • FRS2 signaling is critical for nephron progenitors
  • is an FGF receptor-associated protein required for activation of downstream signaling molecules that include those in the mitogen-activated protein and AKT1 kinase pathways
  • FRS2, FRS3 may act as an important node for FGF and neurotrophin signaling in postnatal hippocampal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • FGFR/FRS2 signaling may play a functional role in the development of high-grade liposarcomas
  • central mediator for fibroblast growth factor signaling
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to GRB2 in response to FGF or nerve growth factor stimulation
  • bind to a tyrosine phosphatase, SHP2 (Minegishi 2009)
  • regulates ERK levels to control a self-renewal target HES1 and proliferation of FGF-responsive neural stem/progenitor cells
  • tyrosine phosphorylation of FRS2 mediates FGFR-dependent lens cell survival, providing a mechanistic basis for the unique fiber-differentiating capacity of FGFs on mammalian lens epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    consistently amplified in classic and dedifferentiated low-grade osteosarcoma (LGOS) but not in their histologic mimics
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpressed FRS2 is a biomarker for Postate carcinoma diagnosis, prognosis and response to therapies
  • Therapy target
    ANIMAL & CELL MODELS